Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AQP4_HUMAN
Description:aquaporin 4 [Source:HGNC Symbol;Acc:637]
Location:chr18 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S316KGKDQsGEVLSCSNK2A1HPRD
S263VEDNRsQVETDCSNK2A1HPRD
S316KGKDQsGEVLSCSNK2A2HPRD
S285VEDNRsQVETDRegPhos
S316KGKDQsGEVLSCK2_groupphosphoELM; RegPhos
S285VEDNRsQVETDCK2_groupphosphoELM; RegPhos
S276QQTKGsYMEVECK2_groupphosphoELM; RegPhos
S285VEDNRsQVETDCK2a1RegPhos
S276QQTKGsYMEVECK2a1-rsRegPhos
S316KGKDQsGEVLSCK2a1RegPhos
S316KGKDQsGEVLSCK2a2RegPhos
S294KGKDQsGEVLSCSNK2A1HPRD
S316KGKDQsGEVLSCK2a1-rsRegPhos
S285VEDNRsQVETDCSNK2A2HPRD
S285VEDNRsQVETDCSNK2A1HPRD
S276QQTKGsYMEVECK2a2RegPhos
S285VEDNRsQVETDCK2a2RegPhos
Y277QTKGSyMEVEDPhosphoSitePlus
S276QQTKGsYMEVECSNK2A2HPRD
S276QQTKGsYMEVECSNK2A1HPRD
S180FASCDsKRTDVMIPPhosphoSitePlus
S254QQTKGsYMEVECSNK2A1HPRD
S285VEDNRsQVETDCK2a1-rsRegPhos
S276QQTKGsYMEVECK2a1RegPhos
S321SGEVLsSVRegPhos

Dephosphorylation site
AQP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372654T137PCOSMICSkin Cancer21984974

Differential expressed protein
AQP4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S180MIPTIFASCDsKRTDVTGastrocytoma19761816PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANAQP4_HUMANkinase -> substrateRegPhos
CSK22_HUMANAQP4_HUMANkinase -> substrateHPRD
CSK21_HUMANAQP4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04962Vasopressin-regulated water reabsorption
hsa04976Bile secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030315T-tubuleIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0015288porin activityIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0006833water transportTASbiological_process
GO:0071392cellular response to estradiol stimulusIEAbiological_process
GO:0070295renal water absorptionIEAbiological_process
GO:0009314response to radiationIEAbiological_process
GO:0015670carbon dioxide transportIEAbiological_process
GO:0005372water transmembrane transporter activityTASmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006833water transportIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0007565female pregnancyIEAbiological_process
GO:0015250water channel activityIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0015250water channel activityEXPmolecular_function
GO:0005215transporter activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0042383sarcolemmaIEAcellular_component
GO:0071346cellular response to interferon-gammaIDAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0050891multicellular organismal water homeostasisIEPbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0051260protein homooligomerizationIEAbiological_process
GO:0007588excretionTASbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0042538hyperosmotic salinity responseIEAbiological_process
GO:0030104water homeostasisIEAbiological_process


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