Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APOA2_HUMAN
Description:apolipoprotein A-II [Source:HGNC Symbol;Acc:601]
Location:chr1 q23.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y37SLVSQyFQTVTApoA-IIPhosphoSitePlus
S35VESLVsQYFQTHPRD
S32EPCVEsLVSQYApoA-IIPhosphoSitePlus
Y37SLVSQyFQTVTHPRD
S32EPCVEsLVSQYHPRD
S35VESLVsQYFQTApoA-IIPhosphoSitePlus
S68SYFEKsKEQLTHPRD

Dephosphorylation site
APOA2_HUMAN do not have dephosphorylation site.

Mutation site
APOA2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356969hepatitis C virusNormal vs. CancertissueUp4.418715028
ENSP00000356969Breast CancerNormal vs. CancertissueDown0.5220739354
ENSP00000356969Brain CancerNormal vs. CancertissueUp6.818056677

Hyperphosphorylation site
APOA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
USF2_HUMANAPOA2_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANAPOA2_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAPOA2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
APOA2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionNAScellular_component
GO:0018158protein oxidationIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0060192negative regulation of lipase activityIEAbiological_process
GO:0008035high-density lipoprotein particle bindingIEAmolecular_function
GO:0030301cholesterol transportIEAbiological_process
GO:0050995negative regulation of lipid catabolic processIDAbiological_process
GO:0045416positive regulation of interleukin-8 biosynthetic IDAbiological_process
GO:0060228phosphatidylcholine-sterol O-acyltransferase activIDAmolecular_function
GO:0034366spherical high-density lipoprotein particleIDAcellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0010903negative regulation of very-low-density lipoproteiIDAbiological_process
GO:0006656phosphatidylcholine biosynthetic processIDAbiological_process
GO:0005319lipid transporter activityIDAmolecular_function
GO:0034364high-density lipoprotein particleIDAcellular_component
GO:0060192negative regulation of lipase activityIDAbiological_process
GO:0033344cholesterol effluxIDAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034370triglyceride-rich lipoprotein particle remodelingIDAbiological_process
GO:0042157lipoprotein metabolic processIEAbiological_process
GO:0031210phosphatidylcholine bindingIDAmolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0030300regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0034361very-low-density lipoprotein particleIDAcellular_component
GO:0070653high-density lipoprotein particle receptor bindingIPImolecular_function
GO:0017127cholesterol transporter activityIDAmolecular_function
GO:0008289lipid bindingIDAmolecular_function
GO:0055102lipase inhibitor activityIDAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0033700phospholipid effluxIDAbiological_process
GO:0046340diacylglycerol catabolic processIDAbiological_process
GO:0034384high-density lipoprotein particle clearanceIDAbiological_process
GO:0032375negative regulation of cholesterol transportIMPbiological_process
GO:0050996positive regulation of lipid catabolic processIDAbiological_process
GO:0043691reverse cholesterol transportIDAbiological_process
GO:0002526acute inflammatory responseIEAbiological_process
GO:0002740negative regulation of cytokine secretion involvedIDAbiological_process
GO:0009395phospholipid catabolic processIDAbiological_process
GO:0031647regulation of protein stabilityIDAbiological_process
GO:0034190apolipoprotein receptor bindingIPImolecular_function
GO:0010873positive regulation of cholesterol esterificationIDAbiological_process
GO:0034375high-density lipoprotein particle remodelingIDAbiological_process
GO:0009749response to glucose stimulusIDAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0006641triglyceride metabolic processTASbiological_process
GO:0060695negative regulation of cholesterol transporter actIDAbiological_process
GO:0034374low-density lipoprotein particle remodelingIDAbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0015485cholesterol bindingIDAmolecular_function
GO:0005543phospholipid bindingIDAmolecular_function
GO:0034380high-density lipoprotein particle assemblyIDAbiological_process
GO:0042632cholesterol homeostasisIDAbiological_process
GO:0042627chylomicronIDAcellular_component
GO:0006869lipid transportIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0060621negative regulation of cholesterol importIDAbiological_process
GO:0006457protein foldingIDAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0018206peptidyl-methionine modificationIDAbiological_process
GO:0017127cholesterol transporter activityIEAmolecular_function