| UniProt/SwissProt ID: | APC7_HUMAN |
| Description: | anaphase promoting complex subunit 7 [Source:HGNC Symbol;Acc:17380] |
| Location: | chr12 q24.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S30 | LLLTMsNNNPE | PLK1 | phosphoELM; RegPhos |
| T126 | GNSAStPQSQC | HPRD | |
| S119 | SKVRPsTGNSA | HPRD | |
| S23 | NVRLLsSLLLT | PLK1 | phosphoELM; RegPhos |
| S17 | AAGLHsNVRLL | PLK1 | phosphoELM; RegPhos |
| T92 | GNSAStPQSQC | phosphoELM | |
| S91 | TGNSAsTPQSQ | phosphoELM | |
| S125 | TGNSAsTPQSQ | HPRD | |
| Dephosphorylation site |
| APC7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000394394 | E556K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000394394 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 2.1 | 16319398 |
| Hyperphosphorylation site |
| APC7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PLK1_HUMAN | APC7_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa05166 | HTLV-I infection |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04110 | Cell cycle |
| hsa04114 | Oocyte meiosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0070979 | protein K11-linked ubiquitination | IDA | biological_process |
| GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0019903 | protein phosphatase binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005680 | anaphase-promoting complex | IDA | cellular_component |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | TAS | biological_process |