Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APC1_HUMAN
Description:anaphase promoting complex subunit 1 [Source:HGNC Symbol;Acc:19988]
Location:chr2 q13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S555EVVLLsPVPELPhosphoSitePlus; HPRD; phosphoELM
S345RSPSIsNMAALPhosphoSitePlus
S731RSLCLsPSEASPhosphoSitePlus; HPRD; phosphoELM
S202EVPPGsPREPLApc1PhosphoSitePlus
T537LDGVStPKPLSCDK1phosphoELM
S377SSHNQsPKRHSCDK1phosphoELM
T291SEQGGtPQNVAPhosphoSitePlus; HPRD; phosphoELM
Y1698KDGVLyVKLRAPhosphoSitePlus
S699KKARPsETGSDPhosphoSitePlus; HPRD; phosphoELM
S536PLDGVsTPKPLPhosphoSitePlus; phosphoELM
S688FEGSLsPVIAPCDK1phosphoELM
S377SSHNQsPKRHSPLK1phosphoELM
Y1552GGEMNyGFHLAPhosphoSitePlus
T530MPRPStPLDGVPLK1phosphoELM
T520PAPSLtMSNTMPhosphoSitePlus; HPRD; phosphoELM
S876RLVVLsIALYIPhosphoSitePlus
S386HSISHsPNSNSPhosphoSitePlus; phosphoELM
S542TPKPLsKLLGSPhosphoSitePlus
S286VVLKFsEQGGTPhosphoSitePlus; HPRD; phosphoELM
S703PSETGsDDDWEPhosphoSitePlus; HPRD; phosphoELM
S688FEGSLsPVIAPPhosphoSitePlus; HPRD; phosphoELM
T520PAPSLtMSNTMPLK1phosphoELM
S364GVHSFsGVQRFPhosphoSitePlus; HPRD; phosphoELM
S355LSRAHsPALGVPLK1phosphoELM
S333QSRSTsSPSLHPhosphoSitePlus; phosphoELM
T530MPRPStPLDGVCDK1phosphoELM
S202EVPPGsPREPLHPRD; phosphoELM
S886ILGDEsLVSDEPhosphoSitePlus
S373RFNISsHNQSPPhosphoSitePlus; phosphoELM
S522PSLTMsNTMPRPhosphoSitePlus; phosphoELM
S362ALGVHsFSGVQPhosphoSitePlus; HPRD; phosphoELM
T537LDGVStPKPLSPhosphoSitePlus; phosphoELM
S300VATSSsLTAHLPhosphoSitePlus
T291SEQGGtPQNVAPLK1phosphoELM
S377SSHNQsPKRHSPhosphoSitePlus; HPRD; phosphoELM
S341SLHSRsPSISNPhosphoSitePlus; HPRD; phosphoELM
S317DSPVTsPFQNYPhosphoSitePlus; HPRD; phosphoELM
T118VYKAFtVDSPVPhosphoSitePlus
S334SRSTSsPSLHSPhosphoSitePlus; phosphoELM
T524LTMSNtMPRPSPhosphoSitePlus; HPRD; phosphoELM
Y1638LLEVTyKGTQWPhosphoSitePlus
S339SPSLHsRSPSIPhosphoSitePlus; phosphoELM
S51SELWSsDGAAGPhosphoSitePlus; HPRD; phosphoELM
S563PELRDsSKLHDHPRD; phosphoELM
S233GSLFGsSRVQYPhosphoSitePlus
T332SQSRStSSPSLPhosphoSitePlus
Y1610ALRHLyVLAAEPhosphoSitePlus
S355LSRAHsPALGVPhosphoSitePlus; HPRD; phosphoELM
S372QRFNIsSHNQSPhosphoSitePlus; HPRD
S343HSRSPsISNMAPhosphoSitePlus; HPRD; phosphoELM
S1707RAGQLsYKEDPPhosphoSitePlus
S688FEGSLsPVIAPPLK1phosphoELM
S555EVVLLsPVPELCDK1phosphoELM
S916EENRFsFRHSTPhosphoSitePlus; phosphoELM
S518GLPAPsLTMSNPhosphoSitePlus; HPRD; phosphoELM
S600VTLELsNGSMVPhosphoSitePlus
S564ELRDSsKLHDSPhosphoSitePlus; HPRD
S529TMPRPsTPLDGPhosphoSitePlus; HPRD; phosphoELM
S1347REKHKsPSYQIPhosphoSitePlus; phosphoELM
Y571LHDSLyNEDCTPhosphoSitePlus; phosphoELM
S686FDFEGsLSPVIPhosphoSitePlus; HPRD; phosphoELM
T530MPRPStPLDGVPhosphoSitePlus; HPRD; phosphoELM
T65SLQEVtIHEKQPhosphoSitePlus; HPRD; phosphoELM
S60AGLVGsLQEVTPhosphoSitePlus; HPRD; phosphoELM
T701ARPSEtGSDDDPhosphoSitePlus; HPRD; phosphoELM
S1349KHKSPsYQIKEPhosphoSitePlus
S336STSSPsLHSRSPhosphoSitePlus
S892LVSDEsSQYLTPhosphoSitePlus
S46QLQPAsELWSSPhosphoSitePlus
S313LSKGDsPVTSPPhosphoSitePlus; HPRD; phosphoELM
S355LSRAHsPALGVCDK1phosphoELM
S50ASELWsSDGAAPhosphoSitePlus; HPRD
S307TAHLRsLSKGDPhosphoSitePlus; HPRD; phosphoELM
T316GDSPVtSPFQNPhosphoSitePlus; phosphoELM
S299NVATSsSLTAHHPRD; phosphoELM
S351NMAALsRAHSPPhosphoSitePlus; phosphoELM
S686FDFEGsLSPVIPLK1phosphoELM
S727HLLNRsLCLSPPhosphoSitePlus; HPRD
S547SKLLGsLDEVVPhosphoSitePlus; HPRD; phosphoELM
T291SEQGGtPQNVACDK1phosphoELM
S569SKLHDsLYNEDPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
APC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339109Q328*COSMICMelanoma21499247
ENSP00000339109Q910RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000339109P651RBIOMARTBreast Cancer21930507, 21930502
ENSP00000339109P859LCOSMICMelanoma21499247
ENSP00000339109M1550KCOSMICSkin Cancer21984974

Differential expressed protein
APC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
APC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANAPC1_HUMANkinase -> substrateRegPhos
CDK1_HUMANAPC1_HUMANkinase -> substrateRegPhos
PLK1_HUMANAPC1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0070979protein K11-linked ubiquitinationIDAbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005680anaphase-promoting complexIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0007067mitosisIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process