Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANM8_HUMAN
Description:protein arginine methyltransferase 8 [Source:HGNC Symbol;Acc:5188]
Location:chr12 p13.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S126GTGILsMFAAKPrmAPhosphoSitePlus
Y189SEWMGyCLFYEPrmAPhosphoSitePlus
Y193GYCLFyESMLNPrmAPhosphoSitePlus
Y222DRAALyVVAIEPhosphoSitePlus
S126GTGILsMFAAKHPRD
T122DVGSGtGILSMHPRD

Dephosphorylation site
ANM8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372067R229KCOSMICSkin Cancer21984974
ENSP00000372067I236TCOSMICCentral Nervous System Neoplasms21163964
ENSP00000372067I250MCOSMICOvarian Cancer21720365
ENSP00000372067M247RCOSMICOvarian Cancer21720365
ENSP00000372067Q35RCOSMICMelanoma21499247
ENSP00000372067L346PCOSMICSkin Cancer21984974
ENSP00000372067W238*COSMICHead and Neck Cancer21798893
ENSP00000372067P56SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ANM8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ANM8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFR2_HUMANANM8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ANM8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0034969histone arginine methylationIDAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimIDAbiological_process
GO:0006479protein methylationIEAbiological_process
GO:0043393regulation of protein bindingTASbiological_process
GO:0035241protein-arginine omega-N monomethyltransferase actIDAmolecular_function
GO:0035242protein-arginine omega-N asymmetric methyltransferIDAmolecular_function
GO:0016571histone methylationIDAbiological_process
GO:0008168methyltransferase activityIEAmolecular_function
GO:0008757S-adenosylmethionine-dependent methyltransferase aIDAmolecular_function
GO:0008276protein methyltransferase activityIEAmolecular_function
GO:0018216peptidyl-arginine methylationIDAbiological_process
GO:0016740transferase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0008469histone-arginine N-methyltransferase activityIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component


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