| UniProt/SwissProt ID: | AMRP_HUMAN |
| Description: | low density lipoprotein receptor-related protein associated protein 1 [Source:HGNC Symbol;Acc:6701] |
| Location: | chr4 p16.3 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T248 | HQGYStEAEFE | Alpha-2-MRAP_C | PhosphoSitePlus |
| S137 | QVTSNsLSGTQ | PhosphoSitePlus | |
| Y336 | TKELGyTVKKH | Alpha-2-MRAP_C | PhosphoSitePlus |
| S45 | NQPKPsPKRES | HPRD | |
| S230 | KEKLRsINQGL | HPRD | |
| S247 | SHQGYsTEAEF | Alpha-2-MRAP_C | PhosphoSitePlus |
| S135 | ARQVTsNSLSG | PhosphoSitePlus | |
| T141 | NSLSGtQEDGL | PhosphoSitePlus | |
| S230 | KEKLRsINQGL | Alpha-2-MRAP_C | PhosphoSitePlus |
| S45 | NQPKPsPKRES | Alpha-2-MRAP_N | PhosphoSitePlus |
| T248 | HQGYStEAEFE | HPRD | |
| S247 | SHQGYsTEAEF | HPRD | |
| Dephosphorylation site |
| AMRP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| AMRP_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000421922 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.3 | 18715028 | ENSP00000421922 | Ovarian Cancer | Treatment (Paclitaxel-sensitive vs. Paclitaxel-resistant) | cell line | Up | 1.3 | 19951750 |
| Hyperphosphorylation site |
| AMRP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AMRP_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| AMRP_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050750 | low-density lipoprotein particle receptor binding | IEA | molecular_function |
| GO:0032091 | negative regulation of protein binding | IDA | biological_process |
| GO:0048237 | rough endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0050750 | low-density lipoprotein particle receptor binding | IDA | molecular_function |
| GO:0070326 | very-low-density lipoprotein particle receptor bin | IPI | molecular_function |
| GO:0048019 | receptor antagonist activity | IDA | molecular_function |
| GO:0004873 | asialoglycoprotein receptor activity | TAS | molecular_function |
| GO:0051082 | unfolded protein binding | TAS | molecular_function |
| GO:0005576 | extracellular region | IDA | cellular_component |
| GO:0031982 | vesicle | IEA | cellular_component |
| GO:0035473 | lipase binding | IEA | molecular_function |
| GO:1900116 | extracellular negative regulation of signal transd | IDA | biological_process |
| GO:0006457 | protein folding | TAS | biological_process |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0016192 | vesicle-mediated transport | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0016021 | integral to membrane | TAS | cellular_component |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0010916 | negative regulation of very-low-density lipoprotei | IDA | biological_process |
| GO:1900222 | negative regulation of beta-amyloid clearance | IGI | biological_process |