| UniProt/SwissProt ID: | AMFR_HUMAN |
| Description: | autocrine motility factor receptor, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:463] |
| Location: | chr16 q12.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T623 | SSDPVtLRRRM | PhosphoSitePlus | |
| S523 | VERPSsDQEEG | PhosphoSitePlus; HPRD; phosphoELM | |
| S509 | TQRSDsIRPAL | HPRD; phosphoELM | |
| S601 | RFLNKsSEDDA | HPRD; phosphoELM | |
| S516 | RPALNsPVERP | PhosphoSitePlus; HPRD; phosphoELM | |
| T548 | PRLEEtLDFGE | PhosphoSitePlus | |
| S542 | VPLDLsPRLEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S522 | PVERPsSDQEE | HPRD; phosphoELM | |
| Dephosphorylation site |
| AMFR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000290649 | Q395* | COSMIC | Skin Cancer | 21984974 | ENSP00000290649 | D605V | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000290649 | L110V | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| AMFR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AMFR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| G6PI_HUMAN | AMFR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0030968 | endoplasmic reticulum unfolded protein response | IMP | biological_process |
| GO:0004842 | ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0000209 | protein polyubiquitination | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051259 | protein oligomerization | IDA | biological_process |
| GO:0030433 | ER-associated protein catabolic process | IDA | biological_process |
| GO:0030176 | integral to endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0004872 | receptor activity | IPI | molecular_function |