Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ALBU_HUMAN
Description:albumin [Source:HGNC Symbol;Acc:399]
Location:chr4 q13.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S18FSSAYsRGVFRPhosphoSitePlus
Y162TFLKKyLYEIAHPRD
Y164LKKYLyEIARRSerum_albuminPhosphoSitePlus
Y521EVDETyVPKEFSerum_albuminPhosphoSitePlus
S82CVADEsAENCDSerum_albuminPhosphoSitePlus
T260VSKLVtDLTKVSerum_albuminPhosphoSitePlus
Y174RHPYFyAPELLSerum_albuminPhosphoSitePlus
T92DKSLHtLFGDKSerum_albuminPhosphoSitePlus
S328PADLPsLAADFSerum_albuminPhosphoSitePlus
Y287ADLAKyICENQSerum_albuminPhosphoSitePlus
Y394DPHECyAKVFDSerum_albuminPhosphoSitePlus
S14LLFLFsSAYSRPhosphoSitePlus
Y108TLRETyGEMADSerum_albuminPhosphoSitePlus
Y377RLAKTyETTLESerum_albuminPhosphoSitePlus
Y108TLRETyGEMADphosphoELM
S336ADFVEsKDVCKSerum_albuminPhosphoSitePlus
Y162TFLKKyLYEIASerum_albuminPhosphoSitePlus
S297QDSISsKLKECHPRD
T551QIKKQtALVELSerum_albuminPhosphoSitePlus
Y521EVDETyVPKEFHPRD
T376LRLAKtYETTLSerum_albuminPhosphoSitePlus
T590ADDKEtCFAEESerum_albuminPhosphoSitePlus
S603KLVAAsQAALGPhosphoSitePlus
T564HKPKAtKEQLKSerum_albuminPhosphoSitePlus
Y17LFSSAySRGVFPhosphoSitePlus
T444VPQVStPTLVESerum_albuminPhosphoSitePlus
T379AKTYEtTLEKCSerum_albuminPhosphoSitePlus
Y343DVCKNyAEAKDSerum_albuminPhosphoSitePlus
T520LEVDEtYVPKESerum_albuminPhosphoSitePlus
Y425EQLGEyKFQNASerum_albuminPhosphoSitePlus
T446QVSTPtLVEVSSerum_albuminPhosphoSitePlus
Y54IAFAQyLQQCPSerum_albuminPhosphoSitePlus
S217EGKASsAKQRLPhosphoSitePlus
S366RHPDYsVVLLLSerum_albuminPhosphoSitePlus
S451TLVEVsRNLGKSerum_albuminPhosphoSitePlus
S443KVPQVsTPTLVSerum_albuminPhosphoSitePlus
T107ATLREtYGEMASerum_albuminPhosphoSitePlus
Y476PCAEDyLSVVLSerum_albuminPhosphoSitePlus
Y164LKKYLyEIARRHPRD; phosphoELM
Y172ARRHPyFYAPESerum_albuminPhosphoSitePlus
S294CENQDsISSKLHPRD
Y365RRHPDySVVLLSerum_albuminPhosphoSitePlus
S82CVADEsAENCDHPRD

Dephosphorylation site
ALBU_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295897E594KCOSMICMelanoma21499247
ENSP00000295897Y174FTCGAOvarian Cancer21720365, 18772890
ENSP00000295897M1ICOSMICMelanoma21499247
ENSP00000295897Y174FCOSMICOvarian Cancer21720365
ENSP00000295897A234DCOSMICOvarian Cancer21720365
ENSP00000295897A234DTCGAOvarian Cancer21720365, 18772890
ENSP00000295897P390SCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000295897hepatitis C virusNormal vs. CancertissueUp4.518715028
ENSP00000295897hepatitis B virusNormal vs. CancertissueDown0.3414726492
ENSP00000295897colorectal cancerNormal vs. CancertissueDown0.4415924290
ENSP00000295897Hepatocellular CarcinomaNormal vs. CancertissueUp2.417627933
ENSP00000295897papillary thyroid carcinomaNormal vs. CancertissueUp1.118665625
ENSP00000295897papillary thyroid carcinomaNormal vs. CancertissueUp218665625
ENSP00000295897Breast CancerNormal vs. CancertissueDown0.416550499
ENSP00000295897Breast CancerNormal vs. CancertissueDown0.6216550499
ENSP00000295897Breast CancerNormal vs. CancertissueUp1.416550499
ENSP00000295897Neoplasms by Histologic TypeNormal vs. CancertissueDown0.7318259946
ENSP00000295897hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000295897Hepatocellular CarcinomaNormal vs. CancertissueUp17447055
ENSP00000295897Hepatocellular CarcinomaCancer vs. CancertissueUp20038311
ENSP00000295897Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000295897Gastric CancerNormal vs. CancertissueDown0.09119424620
ENSP00000295897Gastric CancerNormal vs. CancertissueDown0.1219424620
ENSP00000295897breast ductal carcinomaNormal vs. CancertissueUp0.3820534901
ENSP00000295897breast ductal carcinomaNormal vs. CancertissueUp6920534901
ENSP00000295897Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueDown0.1720602252
ENSP00000295897Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueDown0.2320602252
ENSP00000295897breast ductal carcinomaNormal vs. CancertissueDown18564057
ENSP00000295897Oral CancerNormal vs. CancertissueDown0.1319691830
ENSP00000295897Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.3815169874
ENSP00000295897Uterine CancerNormal vs. CancertissueUp8.819007971
ENSP00000295897Pancreatic CancerNormal vs. CancertissueUp3.716739137
ENSP00000295897pancreatic ductal adenocarcinomaNormal vs. CancertissueDown17492507

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y174Serum_albuminARRHPYFyAPELLFFcholangiocellular carcinoma21253578PhosphoSitePlus
Y108Serum_albuminVATLRETyGEMADCCcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
HNF1A_HUMANALBU_HUMANTF -> target geneTRANSFAC
DBP_HUMANALBU_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ALBU_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043498cell surface bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0019825oxygen bindingIDAmolecular_function
GO:0019836hemolysis by symbiont of host erythrocytesIDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0046010positive regulation of circadian sleep/wake cycle,IEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0051087chaperone bindingIPImolecular_function
GO:0043069negative regulation of programmed cell deathNASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0015643toxin bindingIDAmolecular_function
GO:0006950response to stressIEAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0030170pyridoxal phosphate bindingIDAmolecular_function
GO:0051659maintenance of mitochondrion locationIDAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0043252sodium-independent organic anion transportTASbiological_process
GO:0015721bile acid and bile salt transportTASbiological_process
GO:0005507copper ion bindingNASmolecular_function
GO:0008206bile acid metabolic processTASbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0016209antioxidant activityNASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0009267cellular response to starvationIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0010033response to organic substanceIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0046689response to mercury ionIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0005604basement membraneIEAcellular_component
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0008144drug bindingNASmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0006810transportTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005504fatty acid bindingIDAmolecular_function
GO:0070541response to platinum ionIEAbiological_process