Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AGRIN_HUMAN
Description:agrin [Source:HGNC Symbol;Acc:329]
Location:chr1 p36.33
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1725TLGAWtRVSLELaminin_G_1PhosphoSitePlus
Y217SDASTySNECEKazal_1PhosphoSitePlus
T258CSFGStCARSAPhosphoSitePlus
S218DASTYsNECELKazal_1PhosphoSitePlus
S1159MADPKsELFGESEAPhosphoSitePlus
S204KSPCPsVVAPVKazal_1PhosphoSitePlus
T1165ELFGEtARSIESEAPhosphoSitePlus
S200CVCKKsPCPSVKazal_1PhosphoSitePlus
S257TCSFGsTCARSPhosphoSitePlus
T1275TARATtASRLPPhosphoSitePlus
T1540GPGAAtRGSGVPhosphoSitePlus

Dephosphorylation site
AGRIN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368678C650FCOSMICSkin Cancer21984974
ENSP00000368678E1608QCOSMICBreast Cancer17932254
ENSP00000368678A430VCOSMICSkin Cancer21984974
ENSP00000368678R1604PCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000368678Renal CancerNormal vs. CancertissueUp19164279

Hyperphosphorylation site
AGRIN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AGRIN_HUMANMUSK_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04512ECM-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045162clustering of voltage-gated sodium channelsTASbiological_process
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0051491positive regulation of filopodium assemblyISSbiological_process
GO:0050808synapse organizationTASbiological_process
GO:0033691sialic acid bindingISSmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingTASbiological_process
GO:0005509calcium ion bindingISSmolecular_function
GO:0045202synapseISScellular_component
GO:0031012extracellular matrixIDAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005605basal laminaIDAcellular_component
GO:0043202lysosomal lumenTAScellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0043236laminin bindingTASmolecular_function
GO:0030204chondroitin sulfate metabolic processTASbiological_process
GO:0032321positive regulation of Rho GTPase activityISSbiological_process
GO:0043113receptor clusteringIDAbiological_process
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0045887positive regulation of synaptic growth at neuromusISSbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0006027glycosaminoglycan catabolic processTASbiological_process
GO:0035374chondroitin sulfate bindingISSmolecular_function
GO:0043395heparan sulfate proteoglycan bindingISSmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0002162dystroglycan bindingISSmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006024glycosaminoglycan biosynthetic processTASbiological_process