Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADDG_HUMAN
Description:adducin 3 (gamma) [Source:HGNC Symbol;Acc:245]
Location:chr10 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S442TRWLNsPNTYMPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T59QRKRVtQILQSPhosphoSitePlus
S423DTVPLsPLKYMPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T411IPATVtAFSFEPhosphoSitePlus
S360GVNMGsHQKWKPhosphoSitePlus
T467PRTKItWMKAEPhosphoSitePlus
S649GSPSKsPSKKKHPRD
S683PSKSPsKKKKKPKC_group RegPhos
T651VSRLStSTTIEPhosphoSitePlus
S693KFRTPsFLKKNPKC_groupphosphoELM; RegPhos; SysPTM
Y565GELEEyKRTIEPhosphoSitePlus
T409VEIPAtVTAFSPhosphoSitePlus
S478DSSKVsGGTPIHPRD
S42RERNMsPDLRQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S618RVSRLsTSTTIHPRD
S693KFRTPsFLKKNPKCaRegPhos; SysPTM
T11SQGVItTPPPPHPRD
T691KKKFRtPSFLKPhosphoSitePlus; HPRD
Y35ENDPEyIRERNPhosphoSitePlus
S661KFRTPsFLKKNPRKCAHPRD
T460SRNGEtSPRTKPhosphoSitePlus
T445LNSPNtYMKVNPhosphoSitePlus
S64TQILQsPAFREPhosphoSitePlus; HPRD; phosphoELM
S414TVTAFsFEDDTPhosphoSitePlus
T464ETSPRtKITWMPhosphoSitePlus
S693KFRTPsFLKKNPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S673IEEVLsPEGSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S681GSPSKsPSKKKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S651PSKSPsKKKKKHPRD
Y383LDNLGyRTGYAPhosphoSitePlus; HPRD
Y427LSPLKyMAQRQPhosphoSitePlus
Y389RTGYAyRHPLIPhosphoSitePlus
Y446NSPNTyMKVNVPhosphoSitePlus
S693KFRTPsFLKKNPRKCAHPRD; SysPTM
S683PSKSPsKKKKKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T12QGVITtPPPPSPhosphoSitePlus; HPRD
S187SEATAsNLVKVHPRD
S677LSPEGsPSKSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S652SRLSTsTTIENPhosphoSitePlus
S17TPPPPsMPHKEPhosphoSitePlus
S461RNGETsPRTKIPhosphoSitePlus; HPRD
S647PEGSPsKSPSKHPRD
S650RVSRLsTSTTIPhosphoSitePlus; HPRD
S402KPRHKsDVEIPPhosphoSitePlus; HPRD; RegPhos
S641IEEVLsPEGSPHPRD
T659KKKFRtPSFLKHPRD
S645LSPEGsPSKSPHPRD
S679PEGSPsKSPSKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S180IPRGLsFSEATHPRD

Dephosphorylation site
ADDG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348381N698KCOSMICMelanoma21499247
ENSP00000348381S592XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000348381S592*COSMICIntestines Cancer16959974
ENSP00000348381G458ECOSMICSkin Cancer21984974
ENSP00000353286A261VTCGAOvarian Cancer21720365, 18772890
ENSP00000277900A261VTCGAOvarian Cancer21720365, 18772890
ENSP00000348381E580DCOSMICOvarian Cancer21720365
ENSP00000348381A261VCOSMICOvarian Cancer21720365

Differential expressed protein
ADDG_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADDG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANADDG_HUMANkinase -> substrateRegPhos
KPCA_HUMANADDG_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
ADDG_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046872metal ion bindingIEAmolecular_function
GO:0005198structural molecule activityIEAmolecular_function
GO:0005938cell cortexIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneTAScellular_component
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005200structural constituent of cytoskeletonTASmolecular_function


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