Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACVL1_HUMAN
Description:activin A receptor type II-like 1 [Source:HGNC Symbol;Acc:175]
Location:chr12 q13.13
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y421GIVEDyRPPFYPkinasePhosphoSitePlus
Y375VGTKRyMAPEVPkinasePhosphoSitePlus

Dephosphorylation site
ACVL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373574A49VDing2008Lung Cancer18948947

Differential expressed protein
ACVL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACVL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDF2_HUMANACVL1_HUMANligand -> receptorHPMR
BMP10_HUMANACVL1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
ACVL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001946lymphangiogenesisIEAbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0032332positive regulation of chondrocyte differentiationTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005025transforming growth factor beta receptor activity,IEAmolecular_function
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0023014signal transduction by phosphorylationIEAbiological_process
GO:0016361activin receptor activity, type ITASmolecular_function
GO:0005024transforming growth factor beta-activated receptorIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0060841venous blood vessel developmentIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0043537negative regulation of blood vessel endothelial ceIMPbiological_process
GO:0001937negative regulation of endothelial cell proliferatIEAbiological_process
GO:0061154endothelial tube morphogenesisIMPbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0051895negative regulation of focal adhesion assemblyIMPbiological_process
GO:0010596negative regulation of endothelial cell migrationIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0002043blood vessel endothelial cell proliferation involvTASbiological_process
GO:0043535regulation of blood vessel endothelial cell migratTASbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0008015blood circulationIMPbiological_process
GO:0048185activin bindingIDAmolecular_function
GO:0046332SMAD bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004675transmembrane receptor protein serine/threonine kiRCAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0071773cellular response to BMP stimulusIMPbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIMPbiological_process
GO:0045602negative regulation of endothelial cell differentiIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0045603positive regulation of endothelial cell differentiIEAbiological_process
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:2000279negative regulation of DNA biosynthetic processIMPbiological_process
GO:0030425dendriteIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0035313wound healing, spreading of epidermal cellsIMPbiological_process
GO:0060836lymphatic endothelial cell differentiationIMPbiological_process
GO:0001936regulation of endothelial cell proliferationTASbiological_process
GO:0007162negative regulation of cell adhesionIMPbiological_process
GO:0001955blood vessel maturationTASbiological_process
GO:0050431transforming growth factor beta bindingIPImolecular_function
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006275regulation of DNA replicationTASbiological_process
GO:0008217regulation of blood pressureIMPbiological_process
GO:0061298retina vasculature development in camera-type eyeIEAbiological_process
GO:0060840artery developmentIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0007165signal transductionIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function