Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACSL1_HUMAN
Description:acyl-CoA synthetase long-chain family member 1 [Source:HGNC Symbol;Acc:3569]
Location:chr4 q35.1
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S394LLDFAsKRKEAAMP-bindingPhosphoSitePlus
Y693QIDDLySTIKVPhosphoSitePlus
S58PPCDLsMQSVEHPRD
S103RGIQVsNNGPCPhosphoSitePlus; HPRD
Y567LAQGEyIAPEKAMP-bindingPhosphoSitePlus
Y188NEAITyIVNKAAMP-bindingPhosphoSitePlus
Y577KIENIyMRSEPAMP-bindingPhosphoSitePlus
S394LLDFAsKRKEAHPRD

Dephosphorylation site
ACSL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281455P367LCOSMICOvarian Cancer21720365
ENSP00000281455R8WCOSMICSkin Cancer21984974
ENSP00000281455W611*COSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000281455hepatitis C virusNormal vs. CancertissueDown0.218715028
ENSP00000281455hepatitis B virusNormal vs. CancertissueDown0.0514726492
ENSP00000281455Hepatocellular CarcinomaMetastasiscell lineUp2.819016532
ENSP00000281455Breast CancerNormal vs. CancertissueDown20560667
ENSP00000281455Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
ACSL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CPT1C_HUMANACSL1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04920Adipocytokine signaling pathway
hsa00071Fatty acid metabolism
hsa04146Peroxisome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034201response to oleic acidIEAbiological_process
GO:0004467long-chain fatty acid-CoA ligase activityIEAmolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0010033response to organic substanceIEAbiological_process
GO:0036109alpha-linolenic acid metabolic processTASbiological_process
GO:0001676long-chain fatty acid metabolic processIDAbiological_process
GO:0044539long-chain fatty acid importIDAbiological_process
GO:0008610lipid biosynthetic processIDAbiological_process
GO:0033559unsaturated fatty acid metabolic processTASbiological_process
GO:0015908fatty acid transportIEAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0046320regulation of fatty acid oxidationTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0042178xenobiotic catabolic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0071902positive regulation of protein serine/threonine kiIEAbiological_process
GO:0035338long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0043651linoleic acid metabolic processTASbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0019432triglyceride biosynthetic processTASbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006641triglyceride metabolic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005778peroxisomal membraneIEAcellular_component
GO:0033211adiponectin-mediated signaling pathwayIEAbiological_process


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