Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACAP2_HUMAN
Description:ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [Source:HGNC Symbol;Acc:16469]
Location:chr3 q29
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T749QPGDEtYQDIFPhosphoSitePlus
T358IKAVQtSIATAPHPhosphoSitePlus
Y197MLSFMyAHLAFPhosphoSitePlus
S584TVSANsLYEPEPhosphoSitePlus
Y298NNQLVyQKKFKPHPhosphoSitePlus
Y272IVMEGyLFKRAPHPhosphoSitePlus
S378KLDKKsSPSTGPhosphoSitePlus; HPRD; phosphoELM
S521YSISLsPPEQQPhosphoSitePlus; HPRD
S775RFQQDsQHPRD
S596ERQDSsMFLDSPhosphoSitePlus
S379LDKKSsPSTGSPhosphoSitePlus; HPRD; phosphoELM
Y259DSKLEyNVDAAPhosphoSitePlus
S384SPSTGsLDSGNPhosphoSitePlus; HPRD; phosphoELM
Y742ESEGLyGQPGDPhosphoSitePlus; HPRD; phosphoELM
S387TGSLDsGNESKPhosphoSitePlus
S595GERQDsSMFLDPhosphoSitePlus
S775RFQQDsQKF__PhosphoSitePlus
S581LPSTVsANSLYPhosphoSitePlus
Y750PGDETyQDIFRPhosphoSitePlus; HPRD; phosphoELM
S738EEMREsEGLYGPhosphoSitePlus
Y586SANSLyEPEGEPhosphoSitePlus; HPRD
S381KKSSPsTGSLDPhosphoSitePlus
S519DKYSIsLSPPEPhosphoSitePlus
S540EEKRLsISKFGPhosphoSitePlus

Dephosphorylation site
ACAP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324287K511ICOSMICIntestines Cancer17932254
ENSP00000324287A642VCOSMICOvarian Cancer21720365
ENSP00000324287V649ABIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
ACAP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACAP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANACAP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ACAP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0032312regulation of ARF GTPase activityIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function


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