| UniProt/SwissProt ID: | ACAP2_HUMAN |
| Description: | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [Source:HGNC Symbol;Acc:16469] |
| Location: | chr3 q29 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T749 | QPGDEtYQDIF | PhosphoSitePlus | |
| T358 | IKAVQtSIATA | PH | PhosphoSitePlus |
| Y197 | MLSFMyAHLAF | PhosphoSitePlus | |
| S584 | TVSANsLYEPE | PhosphoSitePlus | |
| Y298 | NNQLVyQKKFK | PH | PhosphoSitePlus |
| Y272 | IVMEGyLFKRA | PH | PhosphoSitePlus |
| S378 | KLDKKsSPSTG | PhosphoSitePlus; HPRD; phosphoELM | |
| S521 | YSISLsPPEQQ | PhosphoSitePlus; HPRD | |
| S775 | RFQQDsQ | HPRD | |
| S596 | ERQDSsMFLDS | PhosphoSitePlus | |
| S379 | LDKKSsPSTGS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y259 | DSKLEyNVDAA | PhosphoSitePlus | |
| S384 | SPSTGsLDSGN | PhosphoSitePlus; HPRD; phosphoELM | |
| Y742 | ESEGLyGQPGD | PhosphoSitePlus; HPRD; phosphoELM | |
| S387 | TGSLDsGNESK | PhosphoSitePlus | |
| S595 | GERQDsSMFLD | PhosphoSitePlus | |
| S775 | RFQQDsQKF__ | PhosphoSitePlus | |
| S581 | LPSTVsANSLY | PhosphoSitePlus | |
| Y750 | PGDETyQDIFR | PhosphoSitePlus; HPRD; phosphoELM | |
| S738 | EEMREsEGLYG | PhosphoSitePlus | |
| Y586 | SANSLyEPEGE | PhosphoSitePlus; HPRD | |
| S381 | KKSSPsTGSLD | PhosphoSitePlus | |
| S519 | DKYSIsLSPPE | PhosphoSitePlus | |
| S540 | EEKRLsISKFG | PhosphoSitePlus | |
| Dephosphorylation site |
| ACAP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000324287 | K511I | COSMIC | Intestines Cancer | 17932254 | ENSP00000324287 | A642V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000324287 | V649A | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ACAP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ACAP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | ACAP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ACAP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0032312 | regulation of ARF GTPase activity | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0008060 | ARF GTPase activator activity | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |