| UniProt/SwissProt ID: | ACADM_HUMAN |
| Description: | acyl-CoA dehydrogenase, C-4 to C-12 straight chain [Source:HGNC Symbol;Acc:89] |
| Location: | chr1 p31.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S320 | EHQAIsFMLAE | Acyl-CoA_dh_1 | PhosphoSitePlus |
| T70 | AEYDKtGEYPV | Acyl-CoA_dh_N | PhosphoSitePlus |
| T300 | ALDEAtKYALE | Acyl-CoA_dh_1 | PhosphoSitePlus |
| Y400 | KIYQIyEGTSQ | Acyl-CoA_dh_1 | PhosphoSitePlus |
| S207 | FLLARsDPDPK | Acyl-CoA_dh_M | PhosphoSitePlus |
| Y73 | DKTGEyPVPLI | Acyl-CoA_dh_N | PhosphoSitePlus |
| T351 | SGRRNtYYASI | Acyl-CoA_dh_1 | PhosphoSitePlus |
| Dephosphorylation site |
| ACADM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359878 | G195R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359878 | P132R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 1363805, 16959974, 1363805, 16959974, 1363805 16959974 | ENSP00000359878 | M1V | COSMIC | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000359878 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.081 | 14654528 | ENSP00000359878 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 3.2 | 14654528 | ENSP00000359878 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.53 | 12923786 | ENSP00000359878 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.59 | 12923786 | ENSP00000359878 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | ENSP00000359878 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.39 | 19610612 |
| Hyperphosphorylation site |
| ACADM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RXRA_HUMAN | ACADM_HUMAN | TF -> target gene | TRANSFAC |
| RARB_HUMAN | ACADM_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ACADM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003995 | acyl-CoA dehydrogenase activity | IDA | molecular_function |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydroge | IEA | biological_process |
| GO:0055114 | oxidation-reduction process | IDA | biological_process |
| GO:0006082 | organic acid metabolic process | IEA | biological_process |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0006635 | fatty acid beta-oxidation | IMP | biological_process |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0044255 | cellular lipid metabolic process | TAS | biological_process |
| GO:0019254 | carnitine metabolic process, CoA-linked | IEA | biological_process |
| GO:0055007 | cardiac muscle cell differentiation | IEA | biological_process |
| GO:0009437 | carnitine metabolic process | IEA | biological_process |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005978 | glycogen biosynthetic process | IEA | biological_process |
| GO:0051793 | medium-chain fatty acid catabolic process | IDA | biological_process |
| GO:0050660 | flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0006111 | regulation of gluconeogenesis | IEA | biological_process |
| GO:0042802 | identical protein binding | IDA | molecular_function |
| GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity | IEA | molecular_function |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0051791 | medium-chain fatty acid metabolic process | IEA | biological_process |
| GO:0042594 | response to starvation | IEA | biological_process |
| GO:0009791 | post-embryonic development | IEA | biological_process |
| GO:0009409 | response to cold | IEA | biological_process |
| GO:0030424 | axon | IDA | cellular_component |
| GO:0001889 | liver development | IEA | biological_process |
| GO:0045329 | carnitine biosynthetic process | IMP | biological_process |