Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACADM_HUMAN
Description:acyl-CoA dehydrogenase, C-4 to C-12 straight chain [Source:HGNC Symbol;Acc:89]
Location:chr1 p31.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S320EHQAIsFMLAEAcyl-CoA_dh_1PhosphoSitePlus
T70AEYDKtGEYPVAcyl-CoA_dh_NPhosphoSitePlus
T300ALDEAtKYALEAcyl-CoA_dh_1PhosphoSitePlus
Y400KIYQIyEGTSQAcyl-CoA_dh_1PhosphoSitePlus
S207FLLARsDPDPKAcyl-CoA_dh_MPhosphoSitePlus
Y73DKTGEyPVPLIAcyl-CoA_dh_NPhosphoSitePlus
T351SGRRNtYYASIAcyl-CoA_dh_1PhosphoSitePlus

Dephosphorylation site
ACADM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359878G195RCOSMICOvarian Cancer21720365
ENSP00000359878P132RSjoblom2006, COSMIC, HPIBreast Cancer1363805, 16959974, 1363805, 16959974, 1363805 16959974
ENSP00000359878M1VCOSMICBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359878hepatitis C virusNormal vs. CancertissueDown0.08114654528
ENSP00000359878Hepatocellular CarcinomaNormal vs. CancertissueUp3.214654528
ENSP00000359878Renal CancerNormal vs. CancertissueDown0.5312923786
ENSP00000359878Renal CancerNormal vs. CancertissueDown0.5912923786
ENSP00000359878Renal CancerNormal vs. CancertissueDown19164279
ENSP00000359878Renal CancerNormal vs. CancertissueDown0.3919610612

Hyperphosphorylation site
ACADM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RXRA_HUMANACADM_HUMANTF -> target geneTRANSFAC
RARB_HUMANACADM_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ACADM_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003995acyl-CoA dehydrogenase activityIDAmolecular_function
GO:0005759mitochondrial matrixTAScellular_component
GO:0033539fatty acid beta-oxidation using acyl-CoA dehydrogeIEAbiological_process
GO:0055114oxidation-reduction processIDAbiological_process
GO:0006082organic acid metabolic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0006635fatty acid beta-oxidationIMPbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0019254carnitine metabolic process, CoA-linkedIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0009437carnitine metabolic processIEAbiological_process
GO:0016627oxidoreductase activity, acting on the CH-CH groupIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0005978glycogen biosynthetic processIEAbiological_process
GO:0051793medium-chain fatty acid catabolic processIDAbiological_process
GO:0050660flavin adenine dinucleotide bindingIEAmolecular_function
GO:0006111regulation of gluconeogenesisIEAbiological_process
GO:0042802identical protein bindingIDAmolecular_function
GO:0070991medium-chain-acyl-CoA dehydrogenase activityIEAmolecular_function
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0051791medium-chain fatty acid metabolic processIEAbiological_process
GO:0042594response to starvationIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0009409response to coldIEAbiological_process
GO:0030424axonIDAcellular_component
GO:0001889liver developmentIEAbiological_process
GO:0045329carnitine biosynthetic processIMPbiological_process


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