Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACACB_HUMAN
Description:acetyl-CoA carboxylase beta [Source:HGNC Symbol;Acc:85]
Location:chr12 q24.11
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1340MTVPIsITNPDACC_centralPhosphoSitePlus
S865SYNGNsYTTYMPhosphoSitePlus
T1641IRQTTtGSAVPACC_centralPhosphoSitePlus
S222MRPSMsGLHLVAMPKa2RegPhos
Y866YNGNSyTTYMKPhosphoSitePlus
S808VLPADsLLNLVPhosphoSitePlus
S222MRPSMsGLHLVPhosphoSitePlus; RegPhos
Y1974LGREVyTSNNQCarboxyl_transPhosphoSitePlus
Y1456NILVDyGLRRIACC_centralPhosphoSitePlus
S2347EILQAsGELSHPhosphoSitePlus
Y1489AEDRIyRHLEPACC_centralPhosphoSitePlus
S222MRPSMsGLHLVPRKAA2HPRD
Y1664LDISLyKEVTDACC_centralPhosphoSitePlus
S222MRPSMsGLHLVAMPK_groupphosphoELM; RegPhos
S220PTMRPsMSGLHRegPhos
Y1560EASFEyLQNEGACC_centralPhosphoSitePlus
T1342VPISItNPDLLACC_centralPhosphoSitePlus
T2458DSPASt_____PhosphoSitePlus
S37ITKSKsEANLIHPRD
Y1988VQIMHyNGVSHCarboxyl_transPhosphoSitePlus
T1342VPISItNPDLLHPRD
S1557ITKEAsFEYLQACC_centralPhosphoSitePlus

Dephosphorylation site
ACACB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341044I751VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000367079T1404ITCGAOvarian Cancer21720365, 18772890
ENSP00000367079R193LCOSMICPancreatic Cancer
ENSP00000341044R615WTCGAOvarian Cancer21720365, 18772890
ENSP00000367079M1253ITCGAOvarian Cancer21720365, 18772890
ENSP00000367079G208DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000367079R1403LCOSMICHead and Neck Cancer21798897
ENSP00000367079R615WTCGAOvarian Cancer21720365, 18772890
ENSP00000367079R2240*COSMICSkin Cancer21984974
ENSP00000341044T1404ITCGAOvarian Cancer21720365, 18772890
ENSP00000367079M1253ICOSMICOvarian Cancer21720365
ENSP00000367079V1103IBIOMARTBreast Cancer21930507, 21930502
ENSP00000341044T1128RTCGAOvarian Cancer21720365, 18772890
ENSP00000367079R193LHPIpancreatic ductal adenocarcinoma18772397
ENSP00000341044R1547GBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000367079T1128RTCGAOvarian Cancer21720365, 18772890
ENSP00000367079T1404ICOSMICOvarian Cancer21720365
ENSP00000367079R615WCOSMICOvarian Cancer21720365
ENSP00000367079G256RCOSMICOvarian Cancer21720365
ENSP00000367079T1128RCOSMICOvarian Cancer21720365
ENSP00000341044M1253ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367079Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ACACB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANACACB_HUMANkinase -> substrateRegPhos
AAKG2_HUMANACACB_HUMANkinase -> substrateKEGG
AAPK2_HUMANACACB_HUMANkinase -> substrateHPRD; RegPhos
ACACB_HUMANCPT1C_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
hsa04910Insulin signaling pathway
hsa00061Fatty acid biosynthesis
hsa00640Propanoate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0003989acetyl-CoA carboxylase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0051289protein homotetramerizationIDAbiological_process
GO:2001295malonyl-CoA biosynthetic processIEAbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0016874ligase activityIEAmolecular_function
GO:0012505endomembrane systemIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0004075biotin carboxylase activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0031325positive regulation of cellular metabolic processTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0006853carnitine shuttleTASbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006084acetyl-CoA metabolic processIDAbiological_process
GO:0046320regulation of fatty acid oxidationTASbiological_process