Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AATF_HUMAN
Description:apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:19235]
Location:chr17 q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S93QTLPGsSDEEIHPRD
S155SVQSIsDFEKFPhosphoSitePlus; HPRD; phosphoELM
S143KSRSHsAKTPGPhosphoSitePlus
S203AGDRNsEDDGVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T410RLLRRtQTKRSPhosphoSitePlus
S320GSEEIsSEDDEHPRD; phosphoELM
T310YLVDGtKPNAGHPRD; phosphoELM
S316KPNAGsEEISSAATF-Che1PhosphoSitePlus
S153GFSVQsISDFEPhosphoSitePlus
S104SDEEGsGDEDSHPRD
S273GPEFSsALKNSHPRD
S109SGDEDsEGLGLHPRD
T146SHSAKtPGFSVPhosphoSitePlus
T67ASLLDtDKRYCPhosphoSitePlus; HPRD
Y305YPDTRyLVDGTHPRD
S63KLASAsLLDTDPhosphoSitePlus
S316KPNAGsEEISSHPRD; phosphoELM
S288KALLRsLVGLQAATF-Che1PhosphoSitePlus
S321SEEISsEDDELAATF-Che1PhosphoSitePlus
S94TLPGSsDEEISHPRD
S20LNPRPsEADPEPhosphoSitePlus
S99SDEEIsDEEGSHPRD
S141SKKSRsHSAKTCHEK2HPRD
S477IERKTsSLDPNTRAUBPhosphoSitePlus
S510VDRKAsKGRKLTRAUBPhosphoSitePlus
T366VYRNRtLQKWHAATF-Che1PhosphoSitePlus
Y117LGLEEyDEDDLHPRD; phosphoELM
S189DDAEDsQGESEPhosphoSitePlus
S321SEEISsEDDELHPRD; phosphoELM
S320GSEEIsSEDDEAATF-Che1PhosphoSitePlus
T310YLVDGtKPNAGAATF-Che1PhosphoSitePlus
T476LIERKtSSLDPHPRD
S218SSVKVsEEVEKHPRD
T412LRRTQtKRSVYPhosphoSitePlus

Dephosphorylation site
AATF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225402Q550ECOSMICOvarian Cancer21720365
ENSP00000225402R516QCOSMICSkin Cancer21984974
ENSP00000225402M180ICOSMICOvarian Cancer21720365

Differential expressed protein
AATF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AATF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CHK2_HUMANAATF_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
AATF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0032929negative regulation of superoxide anion generationIDAbiological_process
GO:2000378negative regulation of reactive oxygen species metIDAbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0040016embryonic cleavageIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0042985negative regulation of amyloid precursor protein bIEAbiological_process
GO:0006974response to DNA damage stimulusIEPbiological_process
GO:0043522leucine zipper domain bindingIPImolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0048156tau protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007346regulation of mitotic cell cycleIEAbiological_process
GO:0043522leucine zipper domain bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0042254ribosome biogenesisIEAbiological_process


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