Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AAK1_HUMAN
Description:AP2 associated kinase 1 [Source:HGNC Symbol;Acc:19679]
Location:chr2 p13.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S327PNVQNsPIPAKHPRD
S235MVNLYsGKIITPkinasePhosphoSitePlus
S327PNVQNsPIPAKPkinasePhosphoSitePlus
T389IQPALtPRKRAPhosphoSitePlus; HPRD; phosphoELM
S18GSGLGsGSSGGPhosphoSitePlus; HPRD
T852QTESVtSNRTDPhosphoSitePlus
S624LTPPSsPKTQRPhosphoSitePlus; HPRD; phosphoELM
T681SGSPRtSQQNVHPRD
T627PSSPKtQRAGHPhosphoSitePlus
S642SDVTHsAVFGVPhosphoSitePlus
Y234EMVNLySGKIIHPRD; phosphoELM
T354PKARLtDPIPTPhosphoSitePlus
Y292HCLIRyMLEPDHPRD
S652VPASKsTQLLQPhosphoSitePlus
Y292HCLIRyMLEPDPkinasePhosphoSitePlus
S20GLGSGsSGGGGPhosphoSitePlus; HPRD
S618GQKVGsLTPPSPhosphoSitePlus; HPRD; phosphoELM
S682GSPRTsQQNVYPhosphoSitePlus; HPRD
Y234EMVNLySGKIIPkinasePhosphoSitePlus
T222IKKYTtLSYRAHPRD; phosphoELM
T359TDPIPtTETSIPhosphoSitePlus
T674KSATTtPSGSPPhosphoSitePlus; HPRD
T653PASKStQLLQAPhosphoSitePlus
S235MVNLYsGKIITHPRD; phosphoELM
Y253LGCLLyKLCYFPkinasePhosphoSitePlus
T221EIKKYtTLSYRHPRD; phosphoELM
S637HRRILsDVTHSPhosphoSitePlus; HPRD; phosphoELM
T640ILSDVtHSAVFPhosphoSitePlus; HPRD; phosphoELM
S21LGSGSsGGGGSPhosphoSitePlus; HPRD; phosphoELM
Y34GLGSGyIGRVFPhosphoSitePlus
S650FGVPAsKSTQLPhosphoSitePlus
S14REQGGsGLGSGPhosphoSitePlus; HPRD
S690NVYNPsEGSTWPhosphoSitePlus
T606PKVQTtPPPAVPhosphoSitePlus; HPRD; phosphoELM
T620KVGSLtPPSSPPhosphoSitePlus; HPRD; phosphoELM
T848RLPSQtESVTSPhosphoSitePlus
Y687SQQNVyNPSEGPhosphoSitePlus
S623SLTPPsSPKTQPhosphoSitePlus; HPRD; phosphoELM
T441PQAPPtPQQTPPhosphoSitePlus; HPRD
S668ASLNKsKSATTPhosphoSitePlus; HPRD
T347AAAKKtQPKARPhosphoSitePlus
S670LNKSKsATTTPPhosphoSitePlus; HPRD; phosphoELM
S731EKLGGsAESLIPhosphoSitePlus; HPRD
T27GGGGStSGLGSHPRD
S846PQRLPsQTESVPhosphoSitePlus
S676ATTTPsGSPRTPhosphoSitePlus; HPRD; phosphoELM
T362IPTTEtSIAPRPhosphoSitePlus
S678TTPSGsPRTSQPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
AAK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385181P679RBIOMARTBreast Cancer21930507, 21930502
ENSP00000385181R141HBIOMARTBreast Cancer21930507, 21930502
ENSP00000386456P679RBIOMARTBreast Cancer21930507, 21930502
ENSP00000386456R141HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
AAK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AAK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAK1_HUMANSOX2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
AAK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005905coated pitIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0043195terminal buttonISScellular_component
GO:0050821protein stabilizationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:2000369regulation of clathrin-mediated endocytosisIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0019897extrinsic to plasma membraneISScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0046777protein autophosphorylationISSbiological_process
GO:0004674protein serine/threonine kinase activityISSmolecular_function
GO:0032880regulation of protein localizationIDAbiological_process
GO:0005112Notch bindingIDAmolecular_function
GO:0035612AP-2 adaptor complex bindingIDAmolecular_function
GO:0030136clathrin-coated vesicleISScellular_component
GO:0045747positive regulation of Notch signaling pathwayIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0031252cell leading edgeISScellular_component


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