Phosphorylation

Protein information

UniProt/SwissProt ID:	AACS_HUMAN
Description:	acetoacetyl-CoA synthetase [Source:HGNC Symbol;Acc:21298]
Location:	chr12 q24.31
Node attribute:	gene

Position	PhosphoPeptide	Catalytic kinase	Source
Y578	PQYNKyREERV		PhosphoSitePlus
Y212	VEAVVyNGKEH	AMP-binding	PhosphoSitePlus
T531	RINPKtGGIVM	AMP-binding	PhosphoSitePlus
Y524	WAHGDyCRINP	AMP-binding	PhosphoSitePlus
Y212	VEAVVyNGKEH		HPRD

AACS_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000324842	P413S	TCGA, COSMIC	Ovarian Cancer	21720365, 18772890
ENSP00000324842	D523Y	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000324842	G188V	COSMIC	Hepatocellular Carcinoma

AACS_HUMAN is not differential expressed protein.

AACS_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
COT2_HUMAN	AACS_HUMAN	TF -> target gene	TRANSFAC

KEGG Pathway

AACS_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0045471	response to ethanol	IEA	biological_process
GO:0030729	acetoacetate-CoA ligase activity	IEA	molecular_function
GO:0071394	cellular response to testosterone stimulus	IEA	biological_process
GO:0001889	liver development	IEA	biological_process
GO:0014074	response to purine-containing compound	IEA	biological_process
GO:0014070	response to organic cyclic compound	IEA	biological_process
GO:0047760	butyrate-CoA ligase activity	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0010243	response to organic nitrogen	IEA	biological_process
GO:0034201	response to oleic acid	IEA	biological_process
GO:0006629	lipid metabolic process	IEA	biological_process
GO:0060612	adipose tissue development	IEA	biological_process
GO:0071333	cellular response to glucose stimulus	IEA	biological_process
GO:0006631	fatty acid metabolic process	IEA	biological_process
GO:0008152	metabolic process	IEA	biological_process
GO:0042594	response to starvation	IEA	biological_process
GO:0032024	positive regulation of insulin secretion	IEA	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0007584	response to nutrient	IEA	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0003824	catalytic activity	IEA	molecular_function
GO:0071397	cellular response to cholesterol	IEA	biological_process
GO:0050872	white fat cell differentiation	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network