Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AACS_HUMAN
Description:acetoacetyl-CoA synthetase [Source:HGNC Symbol;Acc:21298]
Location:chr12 q24.31
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y578PQYNKyREERVPhosphoSitePlus
Y212VEAVVyNGKEHAMP-bindingPhosphoSitePlus
T531RINPKtGGIVMAMP-bindingPhosphoSitePlus
Y524WAHGDyCRINPAMP-bindingPhosphoSitePlus
Y212VEAVVyNGKEHHPRD

Dephosphorylation site
AACS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324842P413STCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000324842D523YTCGAOvarian Cancer21720365, 18772890
ENSP00000324842G188VCOSMICHepatocellular Carcinoma

Differential expressed protein
AACS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AACS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COT2_HUMANAACS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
AACS_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045471response to ethanolIEAbiological_process
GO:0030729acetoacetate-CoA ligase activityIEAmolecular_function
GO:0071394cellular response to testosterone stimulusIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0014074response to purine-containing compoundIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0047760butyrate-CoA ligase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0010243response to organic nitrogenIEAbiological_process
GO:0034201response to oleic acidIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0060612adipose tissue developmentIEAbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0042594response to starvationIEAbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0071397cellular response to cholesterolIEAbiological_process
GO:0050872white fat cell differentiationIEAbiological_process


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