| UniProt/SwissProt ID: | 5HT1D_HUMAN |
| Description: | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled [Source:HGNC Symbol;Acc:5289] |
| Location: | chr1 p36.12 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T61 | NAFVLtTILLT | 7tm_1; TM | PhosphoSitePlus |
| S193 | CLVNTsQISYT | 7tm_1 | PhosphoSitePlus |
| Y137 | IALDRyWAITD | 7tm_1 | PhosphoSitePlus |
| S147 | DALEYsKRRTA | 7tm_1 | PhosphoSitePlus |
| Y235 | NPPSLyGKRFT | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| 5HT1D_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363748 | R177Q | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| 5HT1D_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 5HT1D_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPH1_HUMAN | 5HT1D_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04726 | Serotonergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004993 | serotonin receptor activity | IEA | molecular_function |
| GO:0051378 | serotonin binding | IEA | molecular_function |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007210 | serotonin receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0014827 | intestine smooth muscle contraction | IMP | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0009636 | response to toxin | IEA | biological_process |