Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:3BP5_HUMAN
Description:SH3-domain binding protein 5 (BTK-associated) [Source:HGNC Symbol;Acc:10827]
Location:chr3 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S264ERRRSsAMGPRp38gRegPhos
S375ECSGAsSPECEPhosphoSitePlus
S351SLDLPsPVSLSJNK2RegPhos
T135RAAKEtISLAESH3BP5PhosphoSitePlus
S137AKETIsLAEQRSH3BP5PhosphoSitePlus
S351SLDLPsPVSLSp38gRegPhos
S194SLDLPsPVSLSMAPK9HPRD
S264SQSSTsPEGQAMAPK12HPRD
S194SLDLPsPVSLSMAPK12HPRD
S351SLDLPsPVSLSMAPK12HPRD
S264ERRRSsAMGPRJNK2RegPhos
S421SQSSTsPEGQAMAPK12HPRD; SysPTM
S351SLDLPsPVSLSJNK2(MAPK9RegPhos
S421SQSSTsPEGQAMAPK9HPRD; SysPTM
S351SLDLPsPVSLSp38g(MAPK12RegPhos
Y101EDSKPyWEARRSH3BP5PhosphoSitePlus
S421SQSSTsPEGQAp38g(MAPK12) RegPhos; SysPTM
S418SSKSQsSTSPERegPhos
S376CSGASsPECEVPhosphoSitePlus
S264SQSSTsPEGQAMAPK9HPRD
S421SQSSTsPEGQAPhosphoSitePlus; phosphoELM; SysPTM
S351SLDLPsPVSLSMAPK9HPRD
S421SQSSTsPEGQAp38gRegPhos; SysPTM
S208RAINKsKPYFESH3BP5PhosphoSitePlus; SysPTM
S421SQSSTsPEGQAJNK2RegPhos; SysPTM

Dephosphorylation site
3BP5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373301G409SBIOMARTBreast Cancer21930507, 21930502
ENSP00000388553G252SBIOMARTBreast Cancer21930507, 21930502
ENSP00000253688G252SBIOMARTBreast Cancer21930507, 21930502
ENSP00000386231G252SBIOMARTBreast Cancer21930507, 21930502
ENSP00000373301Q319*COSMICOvarian Cancer21720365

Differential expressed protein
3BP5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
3BP5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK09_HUMAN3BP5_HUMANkinase -> substrateRegPhos
MK12_HUMAN3BP5_HUMANkinase -> substrateHPRD
ZAGL2_HUMAN3BP5_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
3BP5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0004860protein kinase inhibitor activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0035556intracellular signal transductionIDAbiological_process


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