| UniProt/SwissProt ID: | 2A5G_HUMAN |
| Description: | protein phosphatase 2, regulatory subunit B', gamma [Source:HGNC Symbol;Acc:9311] |
| Location: | chr14 q32.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S373 | PIMFPsLYRNS | B56 | PhosphoSitePlus |
| T88 | NRNVItEPIYP | B56 | PhosphoSitePlus |
| Y354 | YWNNEyIMSLI | B56 | PhosphoSitePlus |
| Y349 | ERALYyWNNEY | B56 | PhosphoSitePlus |
| S520 | ADELAsQDGR_ | PhosphoSitePlus | |
| S298 | WPKTHsPKEVM | B56 | PhosphoSitePlus |
| S9 | CNKAGsRMVVD | PhosphoSitePlus | |
| Y348 | AERALyYWNNE | B56 | PhosphoSitePlus |
| S336 | LAKCVsSPHFQ | B56 | PhosphoSitePlus |
| Y375 | MFPSLyRNSKT | B56 | PhosphoSitePlus |
| S497 | LARRKsELPQD | PhosphoSitePlus | |
| Dephosphorylation site |
| 2A5G_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000333905 | D175Y | COSMIC | Skin Cancer | 21984974 | ENSP00000333905 | S447R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000333905 | E122K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| 2A5G_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 2A5G_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1E_HUMAN | 2A5G_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| 2A5G_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000159 | protein phosphatase type 2A complex | IEA | cellular_component |
| GO:0016021 | integral to membrane | IDA | cellular_component |
| GO:0008601 | protein phosphatase type 2A regulator activity | NAS | molecular_function |
| GO:0006977 | DNA damage response, signal transduction by p53 cl | IDA | biological_process |
| GO:0016485 | protein processing | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042771 | intrinsic apoptotic signaling pathway in response | IMP | biological_process |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IMP | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IDA | biological_process |
| GO:0008233 | peptidase activity | IDA | molecular_function |
| GO:0000775 | chromosome, centromeric region | IDA | cellular_component |
| GO:0008601 | protein phosphatase type 2A regulator activity | IEA | molecular_function |