Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZO1_HUMAN
Description:tight junction protein 1 [Source:HGNC Symbol;Acc:11827]
Location:chr15 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1532FTPKPyTSSARPhosphoSitePlus
Y633TKFPAyERVVLPhosphoSitePlus
Y718VDRLNyAQWYPGuanylate_kinPhosphoSitePlus
S340NGSLRsRDEERPhosphoSitePlus
S1490SKTPTsPKTLVHPRD
S1139EPAPLsYDSRPPhosphoSitePlus
S1051VEKQAsRDLEQPhosphoSitePlus
S885PVREDsSGMHHHPRD; SysPTM
T1567DLSSKtPTSPKHPRD
Y830APGSEySMYSTPhosphoSitePlus
Y588LASVQyTLPKTPhosphoSitePlus; HPRD; phosphoELM
Y1039EPNLTyEPQLPPhosphoSitePlus
S1366YFDRRsFENKPPhosphoSitePlus; HPRD; SysPTM
S432FRKGDsVGLRLPDZPhosphoSitePlus
S166ASRERsLSPRSPhosphoSitePlus; HPRD
Y1419FGEKRyEPIQAPhosphoSitePlus; HPRD
Y895HENQTyPPYSPPhosphoSitePlus; HPRD; SysPTM
S831PGSEYsMYSTDPhosphoSitePlus
Y520VGDSFyIRTHFSH3_2PhosphoSitePlus
T1489SSKTPtSPKTLHPRD
Y1602AEKPKyQINNIPhosphoSitePlus
S964PTPAPsTSYSPPhosphoSitePlus
S1577KTLVKsHSLAQHPRD; phosphoELM
Y1066YESSSyTDQFSPhosphoSitePlus
S1439QYAQPsQPVTSPhosphoSitePlus
S1497KTLVKsHSLAQHPRD
S334SPQQPsNGSLRPhosphoSitePlus
T840TDSRHtSDYEDHPRD
S1534PKPYTsSARPFPhosphoSitePlus
S1286YFDRRsFENKPHPRD
S1071YTDQFsRNYEHHPRD; SysPTM
S1196YFEQYsRSYEQPhosphoSitePlus
S1433PPPLPsQYAQPPhosphoSitePlus
S926QKAEAsSPVPYPhosphoSitePlus; HPRD; phosphoELM
Y389EPKPVyAQVGQPhosphoSitePlus
S323QRSEPsDHSRHHPRD; SysPTM
S877SAITRsSEPVRPhosphoSitePlus; HPRD; SysPTM
T1067ESSSYtDQFSRPhosphoSitePlus
S1617KAIPVsPSAVEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T979LRTPStEAAHIPhosphoSitePlus
T772HLFTTtINLNSGuanylate_kinPhosphoSitePlus
S315RSRSRsPDQRSPhosphoSitePlus
S1036SQDLDsRQHPEHPRD
S178RRSVAsSQPAKPhosphoSitePlus; HPRD
T965TPAPStSYSPQHPRD; phosphoELM
S277PDLSDsIHSANPhosphoSitePlus; HPRD; phosphoELM
Y1059LEQPTyRYESSPhosphoSitePlus
S1446PVTSAsLHIHSPhosphoSitePlus
S1444SQPVTsASLHIPhosphoSitePlus
T548FRVVDtLYNGKSH3_2PhosphoSitePlus
S141IHDPRsGRSGVPhosphoSitePlus
S1025KQPAVsHPGHRPhosphoSitePlus
S973SPQADsLRTPSPhosphoSitePlus; HPRD; phosphoELM
Y1146DSRPRyEQAPRPhosphoSitePlus
S828LSAPGsEYSMYPhosphoSitePlus
S1465ERKFEsPKFNHHPRD
S968PSTSYsPQADSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S168RERSLsPRSDRPhosphoSitePlus; HPRD
Y1195QYFEQySRSYEPhosphoSitePlus
T476NNVDFtNIIREPDZPhosphoSitePlus
S1031FDNQHsQDLDSHPRD
S886VREDSsGMHHEPhosphoSitePlus; HPRD
S337QPSNGsLRSRDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1199QYSRSyEQVPPPhosphoSitePlus
Y1346VRSNHyDPEEDPhosphoSitePlus
S585AEQLAsVQYTLPhosphoSitePlus
Y550VVDTLyNGKLGSH3_2PhosphoSitePlus
T1443PSQPVtSASLHPhosphoSitePlus
Y1128SSERGyFPRFEPhosphoSitePlus
S1198EQYSRsYEQVPPhosphoSitePlus
T379RNEKQtPSLPEPhosphoSitePlus; HPRD
S1111FDNQHsQDLDSPhosphoSitePlus; HPRD
Y843RHTSDyEDTDTPhosphoSitePlus; HPRD
Y669EEPDIyQIAKSPhosphoSitePlus
S151VVNRRsEKIWPPhosphoSitePlus
Y1355PLPSQyAQPSQHPRD
S899TYPPYsPQAQPPhosphoSitePlus
S1655IETGVsIIIPQZU5PhosphoSitePlus
S1065RYESSsYTDQFPhosphoSitePlus
Y898QTYPPySPQAQHPRD
T363HADDHtPKTVEPhosphoSitePlus; HPRD; phosphoELM
S1116SQDLDsRQHPEHPRD; SysPTM
Y1361RKQLSyFDRRSPhosphoSitePlus
S212FVKEIsQDSLAPDZPhosphoSitePlus
Y1324HDKTLyRIPEPPhosphoSitePlus
T868NDEVGtPPESAPhosphoSitePlus; HPRD; SysPTM
Y1061QPTYRyESSSYPhosphoSitePlus
T1322SEHDKtLYRIPPhosphoSitePlus
S347DEERIsKPGAVPhosphoSitePlus
S297IQSLAsDHSGRPhosphoSitePlus
T1167APGYDtHGRLRPhosphoSitePlus
S290ERDDIsEIQSLHPRD
T648FLRPVtIFGPIPhosphoSitePlus
T185QPAKPtKVTLVPhosphoSitePlus
Y132NEEDSyDEEIHPhosphoSitePlus; HPRD; phosphoELM
Y1355EDEEYyRKQLSPhosphoSitePlus
S280SDSIHsANASEPhosphoSitePlus; HPRD; phosphoELM
Y967APSTSySPQADPhosphoSitePlus
S837MYSTDsRHTSDPhosphoSitePlus
S1619IPVSPsAVEEDPhosphoSitePlus; phosphoELM
T976ADSLRtPSTEAPhosphoSitePlus; HPRD; phosphoELM
Y1140PAPLSyDSRPRPhosphoSitePlus
T354PGAVStPVKHAPhosphoSitePlus; HPRD; phosphoELM
Y833SEYSMySTDSRPhosphoSitePlus
T1487DLSSKtPTSPKHPRD
S162RDRSAsRERSLPhosphoSitePlus
Y931SSPVPyLSPETPhosphoSitePlus
S1570SKTPTsPKTLVPhosphoSitePlus; HPRD
T1425EPIQAtPPPPPPhosphoSitePlus; HPRD
S160WPRDRsASRERPhosphoSitePlus
S824RLSYLsAPGSEPhosphoSitePlus
T589ASVQYtLPKTAPhosphoSitePlus; HPRD; SysPTM
S144PRSGRsGVVNRPhosphoSitePlus
T854EGGAYtDQELDPhosphoSitePlus
T738KQGVKtMRMRLGuanylate_kinPhosphoSitePlus
T894HHENQtYPPYSPhosphoSitePlus; HPRD; SysPTM
T1058DLEQPtYRYESPhosphoSitePlus
S1537KAIPVsPSAVEHPRD
S927KAEASsPVPYLPhosphoSitePlus; HPRD; phosphoELM
S978SLRTPsTEAAHPhosphoSitePlus
S353KPGAVsTPVKHPhosphoSitePlus; HPRD; phosphoELM
Y822DDRLSyLSAPGPhosphoSitePlus
S1413DGVDRsFGEKRPhosphoSitePlus
Y1191AESKQyFEQYSPhosphoSitePlus
S821HDDRLsYLSAPPhosphoSitePlus
S131DNEEDsYDEEIPhosphoSitePlus; HPRD; phosphoELM
S294ISEIQsLASDHPhosphoSitePlus; HPRD
T709ALLDVtPNAVDHPRD
S125DPEPVsDNEEDPhosphoSitePlus; HPRD; phosphoELM
S300LASDHsGRSHDPhosphoSitePlus; HPRD
S810ADGATsDDLDLPhosphoSitePlus
S1545ERKFEsPKFNHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1451SLHIHsKGAHGPhosphoSitePlus
S1142PLSYDsRPRYEPhosphoSitePlus
S313PRRSRsRSPDQPhosphoSitePlus
Y1524TVTPAyNRFTPPhosphoSitePlus
S179RSVASsQPAKPPhosphoSitePlus; HPRD
S841DSRHTsDYEDTHPRD
S284HSANAsERDDIHPRD
S1064YRYESsSYTDQPhosphoSitePlus
T1345EPIQAtPPPPPHPRD
Y1435PLPSQyAQPSQPhosphoSitePlus; HPRD; phosphoELM
S912IHRIDsPGFKPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S175RSDRRsVASSQPhosphoSitePlus; HPRD
Y1339FGEKRyEPIQAHPRD
Y1165QPAPGyDTHGRPhosphoSitePlus
Y1087DRVPMyEEQWSPhosphoSitePlus
S275NVPDLsDSIHSPhosphoSitePlus; HPRD
S622SREDLsAQPVQPhosphoSitePlus; HPRD; phosphoELM
Y1354EEDEEyYRKQLPhosphoSitePlus
S966PAPSTsYSPQAPhosphoSitePlus
S402VDLPVsPSDGVHPRD
S933PVPYLsPETNPPhosphoSitePlus; HPRD; phosphoELM
S919GFKPAsQQKAEPhosphoSitePlus
S991YTDQFsRNYEHHPRD
S617RNLRKsREDLSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S329DHSRHsPQQPSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1074QFSRNyEHRLRPhosphoSitePlus
T1569SSKTPtSPKTLHPRD

Dephosphorylation site
ZO1_HUMAN do not have dephosphorylation site.

Mutation site
ZO1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000281537Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ZO1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MLTK_HUMANZO1_HUMANkinase -> substrateKEGG
KPCA_HUMANZO1_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa04540Gap junction
hsa05110Vibrio cholerae infection
hsa04520Adherens junction
hsa05132Salmonella infection
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:1901350cell-cell signaling involved in cell-cell junctionNASbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0016327apicolateral plasma membraneIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0043296apical junction complexIDAcellular_component
GO:0005923tight junctionIDAcellular_component
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0046581intercellular canaliculusIEAcellular_component
GO:0035329hippo signaling cascadeTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005923tight junctionIEAcellular_component
GO:0014704intercalated discIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005921gap junctionIEAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0007043cell-cell junction assemblyTASbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0001825blastocyst formationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0043116negative regulation of vascular permeabilityIEAbiological_process
GO:0030054cell junctionIDAcellular_component
GO:0071000response to magnetismIEAbiological_process
GO:0045177apical part of cellIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process