| UniProt/SwissProt ID: | ZN221_HUMAN |
| Description: | zinc finger protein 221 [Source:HGNC Symbol;Acc:13014] |
| Location: | chr19 q13.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y432 | CGKGFyTNSRR | zf-C2H2 | PhosphoSitePlus |
| T333 | HSMVHtGEKAF | PhosphoSitePlus | |
| T305 | HQRIHtGEKPF | BolA | PhosphoSitePlus |
| T249 | HQRVHtGEKPF | PhosphoSitePlus | |
| S605 | SEFTAsFTSVS | PhosphoSitePlus | |
| T473 | HQRVHtGERPY | PhosphoSitePlus | |
| T277 | HCKLHtGEKPY | PhosphoSitePlus | |
| T389 | HQMVHtGEKPY | PhosphoSitePlus | |
| Dephosphorylation site |
| ZN221_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000251269 | F310L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000251269 | H500Y | COSMIC | Melanoma | 21499247 | ENSP00000251269 | K507I | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ZN221_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZN221_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | ZN221_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZN221_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |