Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WWOX_HUMAN
Description:WW domain containing oxidoreductase [Source:HGNC Symbol;Acc:12799]
Location:chr16 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y33KDGWVyYANHTWWPhosphoSitePlus
T12AGLDDtDSEDEPhosphoSitePlus
Y293WAMLAyNRSKLPhosphoSitePlus
S134VTGANsGIGFEadh_shortPhosphoSitePlus
Y33KDGWVyYHPRD
T111RYDGStTAMEIPhosphoSitePlus
Y287PTKNDyWAMLAPhosphoSitePlus
Y33KDGWVyYSRCHPRD
Y61AGDLPyGWEQEphosphoELM
Y33KDGWVyYANHTSRCHPRD
S14LDDTDsEDELPPhosphoSitePlus; HPRD
Y33KDGWVyYANHTHPRD; phosphoELM

Dephosphorylation site
WWOX_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348119K142MCOSMICHead and Neck Cancer21798893
ENSP00000386161V255IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000384238S258PBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
WWOX_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y33WWTTKDGWVyYANHTEEprostate cancer15580310PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANWWOX_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
WWOX_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0006917induction of apoptosisISSbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0046983protein dimerization activityTASmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0055114oxidation-reduction processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0030178negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0008202steroid metabolic processTASbiological_process
GO:0043065positive regulation of apoptotic processISSbiological_process
GO:0005902microvillusIDAcellular_component
GO:0019899enzyme bindingIEAmolecular_function
GO:0048037cofactor bindingTASmolecular_function
GO:0016491oxidoreductase activityTASmolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0048705skeletal system morphogenesisISSbiological_process
GO:0050662coenzyme bindingTASmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005739mitochondrionISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component


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