Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WRN_HUMAN
Description:Werner syndrome, RecQ helicase-like [Source:HGNC Symbol;Acc:12791]
Location:chr8 p12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T777PSRKMtQQVTGPhosphoSitePlus
S1378RCFPGsEEICSPhosphoSitePlus
S1141KAYSSsQPVISATMHPRD; phosphoELM; RegPhos
S467SYVIEsDEDLEPhosphoSitePlus; phosphoELM
T692LGSLKtALPMVDEADPhosphoSitePlus
S1205RIDGVsEGKAAHRDCPhosphoSitePlus
S248EEILLsDMNKQPhosphoSitePlus
S1079LLLPSsKTVSSPhosphoSitePlus
S968AFKLLsAVDILRQCPhosphoSitePlus
S1084SKTVSsGTKEHPhosphoSitePlus
S801AGMSFsTRKDIHelicase_CPhosphoSitePlus
S1120CDKISsGSNISHPRD
S462NENDTsYVIESPhosphoSitePlus
S453MLKHLsPNDNEPhosphoSitePlus; phosphoELM
S1058KANTEsQSLILPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y849DMESYyQEIGRHelicase_CPhosphoSitePlus
S440SYVIEsDEDLEPhosphoSitePlus; HPRD; phosphoELM
S319NLNLLsFEDSTPhosphoSitePlus
S435NENDTsYVIESPhosphoSitePlus
S1133SIMVQsPEKAYPhosphoSitePlus; HPRD
S1141KAYSSsQPVISPhosphoSitePlus; phosphoELM; RegPhos
S1292IGMHLsQAVKAATMHPRD; phosphoELM; RegPhos
S790RKLNLsCGTYHHelicase_CPhosphoSitePlus
Y1112EKLYSyKPCDKPhosphoSitePlus; HPRD
S426STEHLsPNDNEPhosphoSitePlus; HPRD; phosphoELM
S409ILEQQsQEEYLPhosphoSitePlus
S1400NTETSsAERKRHPRD; phosphoELM

Dephosphorylation site
WRN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000298139G92VSjoblom2006Intestines Cancer10220139, 16959974, 21930507, 21930502, 10220139, 16959974
ENSP00000298139I631MTCGAOvarian Cancer21720365, 18772890
ENSP00000298139G92VBIOMART, HPIColorectal Cancer21930507, 21930502, 10220139 16959974
ENSP00000298139L211VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
WRN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WRN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANWRN_HUMANkinase -> substrateRegPhos
ATM_HUMANWRN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
WRN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030145manganese ion bindingIDAmolecular_function
GO:0032389MutLalpha complexIDAcellular_component
GO:0000731DNA synthesis involved in DNA repairIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:00084083'-5' exonuclease activityIDAmolecular_function
GO:0001302replicative cell agingIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0044237cellular metabolic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0000723telomere maintenanceIMPbiological_process
GO:0000405bubble DNA bindingIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004527exonuclease activityIDAmolecular_function
GO:0010259multicellular organismal agingIEAbiological_process
GO:0009267cellular response to starvationIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0032403protein complex bindingIDAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0006139nucleobase-containing compound metabolic processIEAbiological_process
GO:0040009regulation of growth rateIEAbiological_process
GO:0004386helicase activityIDAmolecular_function
GO:0043140ATP-dependent 3'-5' DNA helicase activityIEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIDAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0003678DNA helicase activityIMPmolecular_function
GO:0006284base-excision repairIDAbiological_process
GO:0006200ATP catabolic processIDAbiological_process
GO:0010259multicellular organismal agingIMPbiological_process
GO:0007569cell agingIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005654nucleoplasmIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0051880G-quadruplex DNA bindingIDAmolecular_function
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0031297replication fork processingIMPbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0042981regulation of apoptotic processIGIbiological_process
GO:0007568agingNASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:00431383'-5' DNA helicase activityIDAmolecular_function
GO:0032066nucleolus to nucleoplasm transportIDAbiological_process
GO:0010225response to UV-CIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0006979response to oxidative stressIDAbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0000723telomere maintenanceIEAbiological_process
GO:0006259DNA metabolic processIDAbiological_process
GO:0051345positive regulation of hydrolase activityIDAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0009378four-way junction helicase activityIDAmolecular_function
GO:0006310DNA recombinationIEAbiological_process
GO:0000403Y-form DNA bindingIDAmolecular_function
GO:0006260DNA replicationIMPbiological_process


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