| UniProt/SwissProt ID: | VPS39_HUMAN |
| Description: | vacuolar protein sorting 39 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:20593] |
| Location: | chr15 q15.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S452 | TPTIKsKKKLL | PhosphoSitePlus | |
| S441 | HQSSTsPLMEG | PhosphoSitePlus | |
| T202 | KELFPtGKQLE | CNH | PhosphoSitePlus |
| Dephosphorylation site |
| VPS39_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000326534 | M125V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000326534 | M623L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000326534 | A208T | COSMIC | Pancreatic Cancer | ENSP00000335193 | M634L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000326534 | S184F | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| VPS39_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| VPS39_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK9_HUMAN | VPS39_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| VPS39_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030897 | HOPS complex | IDA | cellular_component |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0005765 | lysosomal membrane | IEA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0031902 | late endosome membrane | IEA | cellular_component |