Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VLDLR_HUMAN
Description:very low density lipoprotein receptor [Source:HGNC Symbol;Acc:12698]
Location:chr9 p24.2
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S846TEEDLsIDIGRPhosphoSitePlus
Y837FDNPVyLKTTEPhosphoSitePlus
S759TTVTYsETKDTPhosphoSitePlus

Dephosphorylation site
VLDLR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371532G795ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000371531D145ATCGAOvarian Cancer21720365, 18772890
ENSP00000371532A771TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000371532A799TCOSMICPancreatic Cancer
ENSP00000371532D145ACOSMICOvarian Cancer21720365
ENSP00000371531G767ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000371532S209NCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000371532Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineUp2.114729644

Hyperphosphorylation site
VLDLR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TFPI1_HUMANVLDLR_HUMANligand -> receptorHPMR
APOE_HUMANVLDLR_HUMANligand -> receptorHPMR
RELN_HUMANVLDLR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
VLDLR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006869lipid transportIEAbiological_process
GO:0030229very-low-density lipoprotein particle receptor actIDAmolecular_function
GO:0034447very-low-density lipoprotein particle clearanceIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007613memoryTASbiological_process
GO:0038026reelin-mediated signaling pathwayIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048306calcium-dependent protein bindingIPImolecular_function
GO:0038025reelin receptor activityIEAmolecular_function
GO:0034361very-low-density lipoprotein particleIEAcellular_component
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0005905coated pitIEAcellular_component
GO:0038025reelin receptor activityISSmolecular_function
GO:0034185apolipoprotein bindingISSmolecular_function
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0034436glycoprotein transportIDAbiological_process
GO:0021517ventral spinal cord developmentIEAbiological_process
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0034189very-low-density lipoprotein particle bindingIDAmolecular_function
GO:0005041low-density lipoprotein receptor activityTASmolecular_function
GO:0034437glycoprotein transporter activityIDAmolecular_function
GO:0006898receptor-mediated endocytosisIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0038026reelin-mediated signaling pathwayISSbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:1900006positive regulation of dendrite developmentISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0001948glycoprotein bindingIPImolecular_function
GO:1900006positive regulation of dendrite developmentIEAbiological_process
GO:0016020membraneIDAcellular_component


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