Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRPV4_HUMAN
Description:transient receptor potential cation channel, subfamily V, member 4 [Source:HGNC Symbol;Acc:18083]
Location:chr12 q24.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y253RRCKHyVELLVLynphosphoELM; RegPhos
Y253RRCKHyVELLVLYNHPRD; RegPhos
S162IVSRGsTADLDPhosphoSitePlus; phosphoELM
T175LPFLLtHKKRLPhosphoSitePlus; phosphoELM
T335AIADNtRENTKAnk_2PhosphoSitePlus
S319MRRQDsRGNTVAnk_2PhosphoSitePlus
Y113FDYGTyRHHSSPhosphoSitePlus
Y411FKDWAyGPVYSHPRD; phosphoELM; RegPhos
T505YPYRTtVDYLRPhosphoSitePlus
S470KFGAVsFYINVTM; DUF4065PhosphoSitePlus
Y508RTTVDyLRLAGPhosphoSitePlus; HPRD
Y253RRCKHyVELLVRegPhos
S824RDRWSsVVPRVPhosphoSitePlus; phosphoELM
Y448RTTVDyLRLAGHPRD
S189EFREPsTGKTCPhosphoSitePlus; phosphoELM
Y91LESTLyESSVVPhosphoSitePlus

Dephosphorylation site
TRPV4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261740V620ICOSMICLymphoma21642962
ENSP00000261740D798GCOSMICOvarian Cancer21720365
ENSP00000261740N204YCOSMICOvarian Cancer21720365
ENSP00000261740P499SCOSMICMelanoma21499247

Differential expressed protein
TRPV4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRPV4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANTRPV4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANTRPV4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TRPV4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005216ion channel activityIEAmolecular_function
GO:0005912adherens junctionISScellular_component
GO:0006811ion transportIEAbiological_process
GO:0007043cell-cell junction assemblyIEAbiological_process
GO:0070509calcium ion importIEAbiological_process
GO:0005034osmosensor activityIEAmolecular_function
GO:0048487beta-tubulin bindingIEAmolecular_function
GO:0051015actin filament bindingIEAmolecular_function
GO:0005261cation channel activityIDAmolecular_function
GO:0005881cytoplasmic microtubuleIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0030027lamellipodiumISScellular_component
GO:0043014alpha-tubulin bindingIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIDAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0043014alpha-tubulin bindingISSmolecular_function
GO:0046785microtubule polymerizationISSbiological_process
GO:0005925focal adhesionISScellular_component
GO:0008017microtubule bindingIEAmolecular_function
GO:0006970response to osmotic stressIEAbiological_process
GO:0006816calcium ion transportNASbiological_process
GO:0048487beta-tubulin bindingISSmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0051015actin filament bindingISSmolecular_function
GO:0005929ciliumIEAcellular_component
GO:0010977negative regulation of neuron projection developmeISSbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0008017microtubule bindingISSmolecular_function
GO:0047484regulation of response to osmotic stressIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0007043cell-cell junction assemblyISSbiological_process
GO:0008219cell deathIEAbiological_process
GO:0007231osmosensory signaling pathwayISSbiological_process
GO:0032587ruffle membraneISScellular_component
GO:0030175filopodiumIEAcellular_component
GO:0007015actin filament organizationIEAbiological_process
GO:0005262calcium channel activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030864cortical actin cytoskeletonISScellular_component
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0006971hypotonic responseIEAbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0007015actin filament organizationISSbiological_process
GO:0030864cortical actin cytoskeletonIEAcellular_component
GO:0032587ruffle membraneIEAcellular_component
GO:0031532actin cytoskeleton reorganizationISSbiological_process
GO:0003779actin bindingISSmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0005516calmodulin bindingIMPmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneISScellular_component
GO:0031117positive regulation of microtubule depolymerizatioISSbiological_process
GO:0030426growth coneISScellular_component
GO:0030175filopodiumISScellular_component
GO:0031117positive regulation of microtubule depolymerizatioIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0071476cellular hypotonic responseISSbiological_process
GO:0030426growth coneIEAcellular_component
GO:0042169SH2 domain bindingISSmolecular_function
GO:0043622cortical microtubule organizationIEAbiological_process
GO:0005080protein kinase C bindingIEAmolecular_function
GO:0031532actin cytoskeleton reorganizationIEAbiological_process
GO:0009612response to mechanical stimulusTASbiological_process
GO:0046785microtubule polymerizationIEAbiological_process
GO:0030103vasopressin secretionIEAbiological_process
GO:0005881cytoplasmic microtubuleISScellular_component
GO:0007231osmosensory signaling pathwayIEAbiological_process
GO:0042538hyperosmotic salinity responseIEAbiological_process
GO:0006884cell volume homeostasisTASbiological_process
GO:0043622cortical microtubule organizationISSbiological_process
GO:0005080protein kinase C bindingISSmolecular_function
GO:0071476cellular hypotonic responseIEAbiological_process
GO:0070509calcium ion importISSbiological_process
GO:0005262calcium channel activityIEAmolecular_function
GO:0055085transmembrane transportIEAbiological_process