Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TP53B_HUMAN
Description:tumor protein p53 binding protein 1 [Source:HGNC Symbol;Acc:11999]
Location:chr15 q15.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1020RKNGStAVAESHPRD
S525SEYSQsPKMESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1647SSSSStTPTRKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S892PSAHAsQSFCEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S888KLGKPsAHASQHPRD
T750AWEEAtSEDSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T302PEVLStQEDLFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S786CSDSQsWEDIAPhosphoSitePlus
T1055SEDPPtTPIRGPhosphoSitePlus; HPRD
S533MESLSsHRIDEPhosphoSitePlus; HPRD
S1426GIEDIsPNLSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1319RTSSGtSLSAMPhosphoSitePlus; HPRD
S1778KQYTEsQLRAGPhosphoSitePlus
S1678SEEERsPAKRGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S6MDPTGsQLDSDPhosphoSitePlus
S640SEALSsVLDQEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S507EDLGLsLTGDSPhosphoSitePlus; HPRD
S301EPEVLsTQEDLPhosphoSitePlus; HPRD
T996LVSPEtEASEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1665SMGVLsGKRKLPhosphoSitePlus; HPRD
S345HLLQLsGQRSLHPRD
S490LTVECsKTSEIHPRD
T313DQSNKtVSSDGPhosphoSitePlus; HPRD
T855LQQPQtQEKTSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S518CKLMLsTSEYSPhosphoSitePlus; HPRD
S877AKQLSsDAEAQPhosphoSitePlus; HPRD; phosphoELM
S1094PMKPIsPVKDPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T338STPATtLHLLQHPRD
S1645TASSSsSTTPTPhosphoSitePlus; HPRD
S698LTETQsQGLCLPhosphoSitePlus
S1460GALRRsDSPEIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1216GDDTEsLHSQGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1646ASSSSsTTPTRPhosphoSitePlus; HPRD
T394DKPMDtSVLSEHPRD
S674ETPCEsQGEELHPRD
S1481GLDASsPGNSFPhosphoSitePlus; HPRD; phosphoELM
Y1552LSEDEyFSAGV53-BP1_TudorPhosphoSitePlus
T1341PLRGKtSGTEPPhosphoSitePlus
S124SVLGMsVESAPPhosphoSitePlus; HPRD
T952ESTIAtSDVMSPhosphoSitePlus
T670EEIPEtPCESQHPRD
S625TCDSGsQAVPSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1290TEVSPsQTGGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1368PRKGVsQTGTPPhosphoSitePlus; HPRD; phosphoELM
S222KHEEQsNEDIPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1316SLHRTsSGTSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1050ENEARsEDPPTHPRD
S1067LLHFPsSQGEEPhosphoSitePlus; HPRD; phosphoELM
S1202QTERGsGEKPVHPRD
T859QTQEKtSNSLTPhosphoSitePlus; HPRD; phosphoELM
S784EKCSDsQSWEDPhosphoSitePlus; phosphoELM; RegPhos
Y1500WSSNGyFYSGK53-BP1_TudorPhosphoSitePlus
S860TQEKTsNSLTEPhosphoSitePlus; HPRD; phosphoELM
T543EDGENtQIEDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S259PPPARsEDMPFHPRD
T1709ESGDNtGEPSAHPRD; phosphoELM
T1654PTRKItESPRAPhosphoSitePlus; HPRD
T519KLMLStSEYSQPhosphoSitePlus; HPRD
T1122GEAMVtDVLEDHPRD; phosphoELM
S1631KRKRRsNVSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y812EKSVEyEGDLKPhosphoSitePlus
S1485SSPGNsFVGLRHPRD
S25LIIEDsQPESQPhosphoSitePlus
S1634RRSNVsSPATPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S523STSEYsQSPKMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S993RMKLVsPETEAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S831VEQDSsQPSLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1330HSSGSsGKGAGPhosphoSitePlus; HPRD
T382VPSSPtEQEGRPhosphoSitePlus; HPRD; phosphoELM
S1673RKLITsEEERSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1430ISPNLsPDDKSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T922PLTGAtPPLIGPhosphoSitePlus; HPRD; phosphoELM
S520LMLSTsEYSQSPhosphoSitePlus; HPRD
S25LIIEDsQPESQATMHPRD; phosphoELM; RegPhos
S1642ATPTAsSSSSTPhosphoSitePlus
T1450DSTRRtDVGAGPhosphoSitePlus; HPRD
S395KPMDTsVLSEEPhosphoSitePlus; HPRD; phosphoELM
S754ATSEDsSVVIVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1028AESVAsPQKTMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1929PSCPAsVLKCABRCTPhosphoSitePlus
S1656RKITEsPRASMPhosphoSitePlus; HPRD
T1638VSSPAtPTASSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S771PRVDVsCEPLEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S830PVEQDsSQPSLHPRD; phosphoELM
S6MDPTGsQLDSDATMRegPhos
T1214APGDDtESLHSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1370KGVSQtGTPVCHPRD; phosphoELM
S265EDMPFsPKASVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S784EKCSDsQSWEDATMHPRD; phosphoELM; RegPhos
S1208GEKPVsAPGDDPhosphoSitePlus; HPRD
S862EKTSNsLTEDSPhosphoSitePlus; HPRD; phosphoELM
S320SSDGCsTPSREPhosphoSitePlus
S330EEGGCsLASTPHPRD
S900FCESSsETPFHPhosphoSitePlus; HPRD
S1320TSSGTsLSAMHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1648SSSSTtPTRKIPhosphoSitePlus; HPRD
S1288CETEVsPSQTGHPRD
S899SFCESsSETPFHPRD; phosphoELM; RegPhos
T1612AVTPLtKAADIPhosphoSitePlus
Y1605YGLGPyEAVTPPhosphoSitePlus; HPRD; phosphoELM
T1394GKAPVtPRGRGPhosphoSitePlus
S532KMESLsSHRIDPhosphoSitePlus
S660PEEGSsGSEVEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S287QELMEsGLQIQPhosphoSitePlus; HPRD
T1315SSLHRtSSGTSPhosphoSitePlus; HPRD
T1756LPDGPtGSSEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1354FALPSsRGGPGPhosphoSitePlus
S1705VSPCEsGDNTGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S280AKEQLsAQELMHPRD
S119PNRTSsVLGMSHPRD
S782GVEKCsDSQSWPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T938PKRHStPIGISPhosphoSitePlus
T214DVDANtAIKHEPhosphoSitePlus; HPRD
S1104PVSPAsQKMVIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1025TAVAEsVASPQPhosphoSitePlus; HPRD
T902ESSSEtPFHFTHPRD
S1113VIQGPsSPQGEPhosphoSitePlus; HPRD; phosphoELM
S1219TESLHsQGEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1148LIERPsQNNIGPhosphoSitePlus
Y1523LFDDGyECDVL53-BP1_TudorPhosphoSitePlus
S359SLSTNsSDLVAPhosphoSitePlus
T1056EDPPTtPIRGNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1759GPTGSsEEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1609PYEAVtPLTKAPhosphoSitePlus; HPRD; phosphoELM
S580GEVQLsQNDDKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T696LSLTEtQSQGLPhosphoSitePlus
S1068LHFPSsQGEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T804ENRLDtKEEKSPhosphoSitePlus
S294LQIQKsPEPEVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S493ECSKTsEIEPKHPRD; phosphoELM
S315SNKTVsSDGCSPhosphoSitePlus; HPRD
S751WEEATsEDSSVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S482DGDMHsSSLTVHPRD
S659HPEEGsSGSEVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1618KAADIsLDNLVPhosphoSitePlus; HPRD; phosphoELM
S379PFIVPsSPTEQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S500IEPKNsPEDLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1344GKTSGtEPADFHPRD
S566PAENDsILMNPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S349LSGQRsLVQDSPhosphoSitePlus
S876NAKQLsSDAEAPhosphoSitePlus; HPRD; phosphoELM
Y188ENTVPyEVDKEPhosphoSitePlus
S63VLDVVsNPEQTPhosphoSitePlus
S1317LHRTSsGTSLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S834DSSQPsLPLVRPhosphoSitePlus; HPRD
S727VISIDsPQKLAHPRD
S166EDTASsQLGFGPhosphoSitePlus; RegPhos
S999PETEAsEESLQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S29DSQPEsQVLEDATMHPRD; phosphoELM; RegPhos
S6LDSDATMHPRD; phosphoELM
T492VECSKtSEIEPHPRD
S316NKTVSsDGCSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1749KLASRsKLPDGPhosphoSitePlus; HPRD; phosphoELM
T486HSSSLtVECSKHPRD
S452SLPIPsQPQFSPhosphoSitePlus; RegPhos
S1480DGLDAsSPGNSPhosphoSitePlus; HPRD; phosphoELM
S1329MHSSGsSGKGAHPRD
T1640SPATPtASSSSPhosphoSitePlus; HPRD
S1160QTMECsLRVPEPhosphoSitePlus
T321SDGCStPSREEPhosphoSitePlus
T586QNDDKtKGDDTPhosphoSitePlus; HPRD
S1462LRRSDsPEIPFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S970DPILGsGKGDSPhosphoSitePlus; HPRD
S1635RSNVSsPATPTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S530SPKMEsLSSHRPhosphoSitePlus
S105TCGSIsQVIEQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S975SGKGDsGAAPDPhosphoSitePlus; HPRD
T337ASTPAtTLHLLPhosphoSitePlus; HPRD
S662EGSSGsEVEEIHPRD; phosphoELM; RegPhos
T1372VSQTGtPVCEEPhosphoSitePlus; HPRD; phosphoELM
S178LELSQsQDVEEPhosphoSitePlus; RegPhos
S1643TPTASsSSSTTPhosphoSitePlus; HPRD
T1156NIGIQtMECSLPhosphoSitePlus
S755TSEDSsVVIVDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1362GPGKLsPRKGVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1114IQGPSsPQGEAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1701AGEFVsPCESGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S894AHASQsFCESSPhosphoSitePlus
S557SPVLNsKFVPAPhosphoSitePlus; HPRD; phosphoELM
T1672KRKLItSEEERPhosphoSitePlus; HPRD; phosphoELM
S176GVLELsQSQDVPhosphoSitePlus; RegPhos
S29DSQPEsQVLEDPhosphoSitePlus
S809TKEEKsVEYEGPhosphoSitePlus; HPRD; phosphoELM
S1474AAAGPsDGLDAPhosphoSitePlus; HPRD; phosphoELM
S1086HTIRQsQQPMKPhosphoSitePlus; HPRD
S1644PTASSsSSTTPPhosphoSitePlus; HPRD
S1019ERKNGsTAVAEHPRD
S366DLVAPsPDAFRPhosphoSitePlus; HPRD
S1758DGPTGsSEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1435SPDDKsFSRVVPhosphoSitePlus; HPRD; phosphoELM
S1002EASEEsLQFNLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S552DTEPMsPVLNSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1171TVSAAtQTIKNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T548TQIEDtEPMSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S635SPATRsEALSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S323GCSTPsREEGGPhosphoSitePlus; HPRD; phosphoELM
S380FIVPSsPTEQEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y522LSTSEySQSPKPhosphoSitePlus; HPRD; phosphoELM
S1342LRGKTsGTEPAPhosphoSitePlus; HPRD; phosphoELM
T334CSLAStPATTLPhosphoSitePlus
S1101VKDPVsPASQKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S639RSEALsSVLDQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1554EDEYFsAGVVK53-BP1_TudorPhosphoSitePlus
S724ETSVIsIDSPQHPRD
S398DTSVLsEEGGEPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
TP53B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263801P1231LCOSMICOvarian Cancer21720365
ENSP00000263801P254SCOSMICOvarian Cancer21720365
ENSP00000263801S1497FCOSMICSkin Cancer21984974
ENSP00000263801S1183RCOSMICMelanoma21499247
ENSP00000263801D1923NCOSMICMelanoma
ENSP00000263801S1635PCOSMICPancreatic Cancer
ENSP00000263801R1583*COSMICIntestines Cancer16959974
ENSP00000263801S1554NCOSMICRenal Cancer20054297
ENSP00000263801L284VCOSMICHead and Neck Cancer21798893
ENSP00000263801M1157RCOSMICOvarian Cancer21720365
ENSP00000263801E1945QBIOMARTBreast Cancer21930507, 21930502
ENSP00000371475E1950QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000371475Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.4419422301

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S1778FNKQYTEsQLRAGAGRIDDLE syndrome17940005PhosphoSitePlus
S25PCLIIEDsQPESQVLataxia-telangiectasia19876065PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANTP53B_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANTP53B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TP53B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0001102RNA polymerase II activating transcription factor IPImolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiICbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0005657replication forkIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0035064methylated histone residue bindingIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0042162telomeric DNA bindingIEAmolecular_function
GO:0000776kinetochoreIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0001104RNA polymerase II transcription cofactor activityIMPmolecular_function
GO:0002039p53 bindingIPImolecular_function
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0005654nucleoplasmTAScellular_component