Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNNI3_HUMAN
Description:troponin I type 3 (cardiac) [Source:HGNC Symbol;Acc:11947]
Location:chr19 q13.42
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S23PIRRRsSNYRAHPRD; RegPhos
S44SKISAsRKLQLPKCaRegPhos
S166ARAKEsLDLRATroponinPhosphoSitePlus
S44SKISAsRKLQLPKCe(PKC epsilonRegPhos
S44SKISAsRKLQLPKC_epsilonphosphoELM
S23PIRRRsSNYRATroponin-I_NPhosphoSitePlus
S24IRRRSsNYRAYHPRD; RegPhos
T78GRALStRCQPLTroponinPhosphoSitePlus
T143KFKRPtLRRVRphosphoELM
T51KLQLKtLLLQITroponinPhosphoSitePlus
Y29SNYRAyATEPHTroponin-I_NPhosphoSitePlus
S42KKSKIsASRKLPRKCAHPRD
S166ARAKEsLDLRAHPRD; phosphoELM; RegPhos
S77KGRALsTRCQPPKCaRegPhos
S150RRVRIsADAMMTroponinPhosphoSitePlus
Y26RRSSNyRAYATTroponin-I_NPhosphoSitePlus
S44SKISAsRKLQLPRKCAHPRD
S24IRRRSsNYRAYTroponin-I_NPhosphoSitePlus
S42KKSKIsASRKLPhosphoSitePlus
S23PIRRRsSNYRAPRKCAHPRD
T31YRAYAtEPHAKTroponin-I_NPhosphoSitePlus
S23PIRRRsSNYRAPKA_groupphosphoELM; RegPhos
S44SKISAsRKLQLPhosphoSitePlus
T143KFKRPtLRRVRPRKCAHPRD
T143KFKRPtLRRVRPKCaRegPhos
S24IRRRSsNYRAYPKA_groupphosphoELM; RegPhos
S199NIDALsGMEGRPhosphoSitePlus
S24IRRRSsNYRAYPRKCAHPRD
S77KGRALsTRCQPPRKCAHPRD
S23PIRRRsSNYRAPKCaRegPhos
T143KFKRPtLRRVRTroponinPhosphoSitePlus
T129EIADLtQKIFDTroponin; DUF919PhosphoSitePlus
S39HAKKKsKISASPhosphoSitePlus; HPRD; RegPhos
Y112VDEERyDIEAKTroponin; DUF919PhosphoSitePlus
S42KKSKIsASRKLPKCaRegPhos
S77KGRALsTRCQPTroponinPhosphoSitePlus
S24IRRRSsNYRAYPKCaRegPhos
T181VKKEDtEKENRPhosphoSitePlus
S6MADGSsDAARETroponin-I_NPhosphoSitePlus
S150RRVRIsADAMMPAK3phosphoELM; RegPhos
S5_MADGsSDAARTroponin-I_NPhosphoSitePlus

Dephosphorylation site
TNNI3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341838H34QCOSMICPancreatic Cancer

Differential expressed protein
TNNI3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S24Troponin-I_NAPIRRRSsNYRAYATDCM22972900PhosphoSitePlus
S5Troponin-I_N___MADGsSDAAREPDCM22972900PhosphoSitePlus
S23Troponin-I_NPAPIRRRsSNYRAYADCM22972900PhosphoSitePlus
S6Troponin-I_N__MADGSsDAAREPRDCM22972900PhosphoSitePlus
Y26Troponin-I_NIRRRSSNyRAYATEPDCM22972900PhosphoSitePlus
T78TroponinEKGRALStRCQPLELDCM22972900PhosphoSitePlus
S42AKKKSKIsASRKLQLDCM22972900PhosphoSitePlus
S77TroponinGEKGRALsTRCQPLEDCM22972900PhosphoSitePlus
S44KKSKISAsRKLQLKTDCM22972900PhosphoSitePlus
T181KQVKKEDtEKENREVDCM22972900PhosphoSitePlus
S166TroponinLGARAKEsLDLRAHLDCM22972900PhosphoSitePlus
T143TroponinRGKFKRPtLRRVRISDCM22972900PhosphoSitePlus
S199RKNIDALsGMEGRKKDCM22972900PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTNNI3_HUMANkinase -> substrateRegPhos
PAK3_HUMANTNNI3_HUMANkinase -> substrateRegPhos
KPCA_HUMANTNNI3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0055010ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0003779actin bindingIDAmolecular_function
GO:0043292contractile fiberIEAcellular_component
GO:0030017sarcomereTAScellular_component
GO:0048306calcium-dependent protein bindingIPImolecular_function
GO:0001570vasculogenesisIEAbiological_process
GO:0019904protein domain specific bindingIPImolecular_function
GO:0030017sarcomereIEAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0060047heart contractionIMPbiological_process
GO:0019855calcium channel inhibitor activityIPImolecular_function
GO:0030049muscle filament slidingTASbiological_process
GO:0006941striated muscle contractionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031014troponin T bindingIPImolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0001980regulation of systemic arterial blood pressure by ISSbiological_process
GO:0007507heart developmentISSbiological_process
GO:0060048cardiac muscle contractionIMPbiological_process
GO:0005861troponin complexIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0006940regulation of smooth muscle contractionIEAbiological_process
GO:0006874cellular calcium ion homeostasisISSbiological_process
GO:0001980regulation of systemic arterial blood pressure by IEAbiological_process
GO:0006937regulation of muscle contractionIEAbiological_process
GO:0032780negative regulation of ATPase activityIMPbiological_process
GO:0030172troponin C bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0001570vasculogenesisISSbiological_process


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