| UniProt/SwissProt ID: | TNFC_HUMAN |
| Description: | lymphotoxin beta (TNF superfamily, member 3) [Source:HGNC Symbol;Acc:6711] |
| Location: | chrHSCHR6_MHC_COX p2 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| TNFC_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| TNFC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000416113 | *78Y | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| TNFC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TNFC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNFC_HUMAN | TNR5_HUMAN | ligand -> receptor | HPMR |
| TNFC_HUMAN | TNR3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05323 | Rheumatoid arthritis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0048535 | lymph node development | IEA | biological_process |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0045084 | positive regulation of interleukin-12 biosynthetic | IEA | biological_process |
| GO:0010467 | gene expression | IEA | biological_process |
| GO:0043588 | skin development | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0045084 | positive regulation of interleukin-12 biosynthetic | ISS | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |