| UniProt/SwissProt ID: | TLE4_HUMAN |
| Description: | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11840] |
| Location: | chr9 q21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T325 | VSKSNtPTPRT | PhosphoSitePlus; HPRD; phosphoELM | |
| S226 | NSADYsSESKK | PhosphoSitePlus | |
| S706 | ESCVLsLKFAH | WD40 | PhosphoSitePlus |
| S222 | EKHRNsADYSS | PhosphoSitePlus | |
| S245 | AARYDsDGEKS | PhosphoSitePlus; HPRD | |
| S292 | KDAPIsPASIA | PhosphoSitePlus; HPRD | |
| S250 | SDGEKsDDNLV | PhosphoSitePlus; HPRD | |
| S227 | SADYSsESKKQ | PhosphoSitePlus | |
| S250 | SDGEKsDDNLV | CK2_group | RegPhos |
| S321 | STTPVsKSNTP | PhosphoSitePlus; HPRD; phosphoELM | |
| S305 | SSTPSsKSKEL | HPRD | |
| S208 | KSSSVsPSASF | PhosphoSitePlus; HPRD | |
| S273 | GSPAHsPRENG | PhosphoSitePlus; HPRD | |
| S264 | SNEDPsSPRGS | HPRD | |
| S206 | SIKSSsVSPSA | PhosphoSitePlus; HPRD | |
| S702 | LHLHEsCVLSL | WD40 | PhosphoSitePlus |
| S299 | ASIASsSSTPS | PhosphoSitePlus | |
| Y225 | RNSADySSESK | PhosphoSitePlus | |
| S269 | SSPRGsPAHSP | PhosphoSitePlus; HPRD | |
| S265 | NEDPSsPRGSP | CDC2 | RegPhos |
| S265 | NEDPSsPRGSP | HPRD | |
| T318 | NEKSTtPVSKS | HPRD; phosphoELM | |
| T282 | NGLDKtRLLKK | PhosphoSitePlus | |
| S295 | PISPAsIASSS | PhosphoSitePlus | |
| S323 | TPVSKsNTPTP | PhosphoSitePlus; HPRD; phosphoELM | |
| T317 | LNEKStTPVSK | PhosphoSitePlus | |
| Y695 | TKPDKyQLHLH | WD40 | PhosphoSitePlus |
| Y243 | EIAARyDSDGE | PhosphoSitePlus; HPRD | |
| T302 | ASSSStPSSKS | PhosphoSitePlus | |
| Dephosphorylation site |
| TLE4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365735 | R214* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| TLE4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TLE4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | TLE4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| TLE4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IEA | molecular_function |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0070491 | repressing transcription factor binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0003674 | molecular_function | ND | molecular_function |