Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLE4_HUMAN
Description:transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11840]
Location:chr9 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T325VSKSNtPTPRTPhosphoSitePlus; HPRD; phosphoELM
S226NSADYsSESKKPhosphoSitePlus
S706ESCVLsLKFAHWD40PhosphoSitePlus
S222EKHRNsADYSSPhosphoSitePlus
S245AARYDsDGEKSPhosphoSitePlus; HPRD
S292KDAPIsPASIAPhosphoSitePlus; HPRD
S250SDGEKsDDNLVPhosphoSitePlus; HPRD
S227SADYSsESKKQPhosphoSitePlus
S250SDGEKsDDNLVCK2_group RegPhos
S321STTPVsKSNTPPhosphoSitePlus; HPRD; phosphoELM
S305SSTPSsKSKELHPRD
S208KSSSVsPSASFPhosphoSitePlus; HPRD
S273GSPAHsPRENGPhosphoSitePlus; HPRD
S264SNEDPsSPRGSHPRD
S206SIKSSsVSPSAPhosphoSitePlus; HPRD
S702LHLHEsCVLSLWD40PhosphoSitePlus
S299ASIASsSSTPSPhosphoSitePlus
Y225RNSADySSESKPhosphoSitePlus
S269SSPRGsPAHSPPhosphoSitePlus; HPRD
S265NEDPSsPRGSPCDC2RegPhos
S265NEDPSsPRGSPHPRD
T318NEKSTtPVSKSHPRD; phosphoELM
T282NGLDKtRLLKKPhosphoSitePlus
S295PISPAsIASSSPhosphoSitePlus
S323TPVSKsNTPTPPhosphoSitePlus; HPRD; phosphoELM
T317LNEKStTPVSKPhosphoSitePlus
Y695TKPDKyQLHLHWD40PhosphoSitePlus
Y243EIAARyDSDGEPhosphoSitePlus; HPRD
T302ASSSStPSSKSPhosphoSitePlus

Dephosphorylation site
TLE4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365735R214*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
TLE4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLE4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANTLE4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TLE4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007219Notch signaling pathwayTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0008150biological_processNDbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005634nucleusNAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0070491repressing transcription factor bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0003674molecular_functionNDmolecular_function


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