| UniProt/SwissProt ID: | THOP1_HUMAN |
| Description: | thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:11793] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y412 | VVGKFyLDLYP | HPRD | |
| S643 | GMDYRsCILRP | PKA_group | phosphoELM; RegPhos |
| Y278 | HTHADyVLEMN | Peptidase_M3 | PhosphoSitePlus |
| Y416 | FYLDLyPREGK | HPRD | |
| T347 | NQVEEtRYCVD | Peptidase_M3 | PhosphoSitePlus |
| T347 | NQVEEtRYCVD | HPRD | |
| S643 | GMDYRsCILRP | PRKACA | HPRD |
| T99 | IRTAStEADKK | PhosphoSitePlus | |
| Y422 | PREGKyGHAAC | Peptidase_M3 | PhosphoSitePlus |
| Y412 | VVGKFyLDLYP | Peptidase_M3 | PhosphoSitePlus |
| Y221 | KVTLKyPHYFP | PhosphoSitePlus | |
| Y422 | PREGKyGHAAC | HPRD | |
| S643 | GMDYRsCILRP | PKACa | RegPhos |
| Y416 | FYLDLyPREGK | Peptidase_M3 | PhosphoSitePlus |
| Y278 | HTHADyVLEMN | RegPhos | |
| S19 | AASPCsVVNDL | PhosphoSitePlus | |
| Dephosphorylation site |
| THOP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000304467 | D109N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304467 | L182M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304467 | D109N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000304467 | A573V | COSMIC | Skin Cancer | 21984974 | ENSP00000304467 | L182M | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| THOP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| THOP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | THOP1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | THOP1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04614 | Renin-angiotensin system |
| hsa05143 | African trypanosomiasis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | molecular_function |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0042277 | peptide binding | IEA | molecular_function |
| GO:0006518 | peptide metabolic process | IEA | biological_process |