Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THOP1_HUMAN
Description:thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:11793]
Location:chr19 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y412VVGKFyLDLYPHPRD
S643GMDYRsCILRPPKA_groupphosphoELM; RegPhos
Y278HTHADyVLEMNPeptidase_M3PhosphoSitePlus
Y416FYLDLyPREGKHPRD
T347NQVEEtRYCVDPeptidase_M3PhosphoSitePlus
T347NQVEEtRYCVDHPRD
S643GMDYRsCILRPPRKACAHPRD
T99IRTAStEADKKPhosphoSitePlus
Y422PREGKyGHAACPeptidase_M3PhosphoSitePlus
Y412VVGKFyLDLYPPeptidase_M3PhosphoSitePlus
Y221KVTLKyPHYFPPhosphoSitePlus
Y422PREGKyGHAACHPRD
S643GMDYRsCILRPPKACaRegPhos
Y416FYLDLyPREGKPeptidase_M3PhosphoSitePlus
Y278HTHADyVLEMNRegPhos
S19AASPCsVVNDLPhosphoSitePlus

Dephosphorylation site
THOP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000304467D109NCOSMICOvarian Cancer21720365
ENSP00000304467L182MCOSMICOvarian Cancer21720365
ENSP00000304467D109NTCGAOvarian Cancer21720365, 18772890
ENSP00000304467A573VCOSMICSkin Cancer21984974
ENSP00000304467L182MTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
THOP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
THOP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTHOP1_HUMANkinase -> substrateRegPhos
KPCA_HUMANTHOP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04614Renin-angiotensin system
hsa05143African trypanosomiasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008233peptidase activityIEAmolecular_function
GO:0004222metalloendopeptidase activityIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0042277peptide bindingIEAmolecular_function
GO:0006518peptide metabolic processIEAbiological_process


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