| UniProt/SwissProt ID: | THOC5_HUMAN |
| Description: | THO complex 5 [Source:HGNC Symbol;Acc:19074] |
| Location: | chr22 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T321 | AEEEQtTKRRR | FimP | PhosphoSitePlus |
| S5 | KKRK | PRKCA | HPRD |
| S347 | KRHPLsVMLDL | HPRD | |
| S312 | SQDDEsDSDAE | HPRD; phosphoELM; RegPhos | |
| S210 | YRECLsNKEKI | FimP | PhosphoSitePlus |
| S5 | MSSESsKKRK | PKCa | RegPhos |
| T328 | KRRRPtLGVQL | FimP | PhosphoSitePlus |
| S293 | VAIEGsVDEAK | FimP | PhosphoSitePlus |
| S28 | GKRNRsDTEQE | PhosphoSitePlus | |
| Y225 | EVKKEyLSSLQ | FimP | PhosphoSitePlus |
| T328 | KRRRPtLGVQL | HPRD; RegPhos | |
| S5 | MSSESsKKRK | RegPhos | |
| S307 | KPPEDsQDDES | HPRD; phosphoELM; RegPhos | |
| S5 | MSSESsKKRK | PKCa(PKC alpha | RegPhos |
| S312 | SQDDEsDSDAE | FimP | PhosphoSitePlus |
| S16 | PKVIRsDGAPA | PhosphoSitePlus; HPRD | |
| S314 | DDESDsDAEEE | HPRD; phosphoELM; RegPhos | |
| S2 | ESSK | HPRD | |
| S6 | KRKP | PKC_alpha | phosphoELM |
| S3 | SSKK | HPRD | |
| Y37 | QEGKYySEEAE | PhosphoSitePlus | |
| S6 | MSSESsKKRKP | PKCa | RegPhos |
| S314 | DDESDsDAEEE | FimP | PhosphoSitePlus |
| S347 | KRHPLsVMLDL | FimP | PhosphoSitePlus |
| T30 | RNRSDtEQEGK | PhosphoSitePlus | |
| S307 | KPPEDsQDDES | FimP | PhosphoSitePlus |
| S5 | _MSSEsSKKRK | PhosphoSitePlus | |
| S6 | MSSESsKKRKP | PKCa(PKC alpha | RegPhos |
| S6 | KRKP | PRKCA | HPRD |
| S5 | KKRK | PKC_alpha | phosphoELM |
| T322 | EEEQTtKRRRP | HPRD; phosphoELM | |
| T321 | AEEEQtTKRRR | HPRD; phosphoELM | |
| Y420 | NPANQyQFDKV | FimP | PhosphoSitePlus |
| S6 | MSSESsKKRKP | PhosphoSitePlus; RegPhos | |
| Dephosphorylation site |
| THOC5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380969 | A189T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000380971 | T380K | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000380970 | T380K | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000380971 | G499S | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000380969 | G499S | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000380970 | G499S | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000380971 | D423H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000380969 | D423H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000380969 | T380K | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000420306 | D423H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420306 | G499S | HPI | Breast Cancer | 16959974 | ENSP00000380970 | D423H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420306 | T380K | HPI | Breast Cancer | 16959974 | ENSP00000380969 | L216V | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| THOC5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| THOC5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | THOC5_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | THOC5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045111 | intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0000445 | THO complex part of transcription export complex | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | IDA | biological_process |
| GO:0000347 | THO complex | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0060215 | primitive hemopoiesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000346 | transcription export complex | IDA | cellular_component |
| GO:0045650 | negative regulation of macrophage differentiation | IEA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046784 | intronless viral mRNA export from host nucleus | IDA | biological_process |
| GO:0030224 | monocyte differentiation | IDA | biological_process |