Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THOC5_HUMAN
Description:THO complex 5 [Source:HGNC Symbol;Acc:19074]
Location:chr22 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T321AEEEQtTKRRRFimPPhosphoSitePlus
S5KKRKPRKCAHPRD
S347KRHPLsVMLDLHPRD
S312SQDDEsDSDAEHPRD; phosphoELM; RegPhos
S210YRECLsNKEKIFimPPhosphoSitePlus
S5MSSESsKKRKPKCaRegPhos
T328KRRRPtLGVQLFimPPhosphoSitePlus
S293VAIEGsVDEAKFimPPhosphoSitePlus
S28GKRNRsDTEQEPhosphoSitePlus
Y225EVKKEyLSSLQFimPPhosphoSitePlus
T328KRRRPtLGVQLHPRD; RegPhos
S5MSSESsKKRKRegPhos
S307KPPEDsQDDESHPRD; phosphoELM; RegPhos
S5MSSESsKKRKPKCa(PKC alphaRegPhos
S312SQDDEsDSDAEFimPPhosphoSitePlus
S16PKVIRsDGAPAPhosphoSitePlus; HPRD
S314DDESDsDAEEEHPRD; phosphoELM; RegPhos
S2ESSKHPRD
S6KRKPPKC_alphaphosphoELM
S3SSKKHPRD
Y37QEGKYySEEAEPhosphoSitePlus
S6MSSESsKKRKPPKCaRegPhos
S314DDESDsDAEEEFimPPhosphoSitePlus
S347KRHPLsVMLDLFimPPhosphoSitePlus
T30RNRSDtEQEGKPhosphoSitePlus
S307KPPEDsQDDESFimPPhosphoSitePlus
S5_MSSEsSKKRKPhosphoSitePlus
S6MSSESsKKRKPPKCa(PKC alphaRegPhos
S6KRKPPRKCAHPRD
S5KKRKPKC_alphaphosphoELM
T322EEEQTtKRRRPHPRD; phosphoELM
T321AEEEQtTKRRRHPRD; phosphoELM
Y420NPANQyQFDKVFimPPhosphoSitePlus
S6MSSESsKKRKPPhosphoSitePlus; RegPhos

Dephosphorylation site
THOC5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380969A189TCOSMICHead and Neck Cancer21798893
ENSP00000380971T380KSjoblom2006, HPIBreast Cancer16959974
ENSP00000380970T380KSjoblom2006, HPIBreast Cancer16959974
ENSP00000380971G499SSjoblom2006, HPIBreast Cancer16959974
ENSP00000380969G499SSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000380970G499SSjoblom2006, HPIBreast Cancer16959974
ENSP00000380971D423HBIOMARTBreast Cancer21930507, 21930502
ENSP00000380969D423HBIOMARTBreast Cancer21930507, 21930502
ENSP00000380969T380KSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000420306D423HBIOMARTBreast Cancer21930507, 21930502
ENSP00000420306G499SHPIBreast Cancer16959974
ENSP00000380970D423HBIOMARTBreast Cancer21930507, 21930502
ENSP00000420306T380KHPIBreast Cancer16959974
ENSP00000380969L216VCOSMICBreast Cancer20668451

Differential expressed protein
THOC5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
THOC5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTHOC5_HUMANkinase -> substrateRegPhos
KPCA_HUMANTHOC5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0000445THO complex part of transcription export complexIDAcellular_component
GO:0006406mRNA export from nucleusIDAbiological_process
GO:0000347THO complexIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0060215primitive hemopoiesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0000346transcription export complexIDAcellular_component
GO:0045650negative regulation of macrophage differentiationIEAbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0006397mRNA processingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046784intronless viral mRNA export from host nucleusIDAbiological_process
GO:0030224monocyte differentiationIDAbiological_process


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