Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TFR1_HUMAN
Description:transferrin receptor (p90, CD71) [Source:HGNC Symbol;Acc:11763]
Location:chr3 q29
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S24SYTRFsLARQVPKC_groupphosphoELM; RegPhos
S24SYTRFsLARQVPKC_alphaphosphoELM
S499FKVSAsPLLYTHPRD
Y19GGEPLsYTRFSHPRD
S24SYTRFsLARQVPKCa(PKC alphaRegPhos
S24SYTRFsLARQVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S19GGEPLsYTRFSPhosphoSitePlus; HPRD; phosphoELM
Y573TTMDTyKELIEPhosphoSitePlus
Y20GEPLSyTRFSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y282IGVLIyMDQTKPAPhosphoSitePlus
S34VDGDNsHVEMKPhosphoSitePlus; HPRD
Y503ASPLLyTLIEKHPRD
T572GTTMDtYKELIPhosphoSitePlus
T21EPLSYtRFSLAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T286IYMDQtKFPIVPAPhosphoSitePlus
T658TSRLTtDFGNAHPRD; SysPTM

Dephosphorylation site
TFR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353224Y282SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353224T658RCOSMICOvarian Cancer21720365
ENSP00000376197Y282SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353224Y563CCOSMICOvarian Cancer21720365
ENSP00000353224R155HCOSMICOvarian Cancer21720365
ENSP00000353224F297LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376197Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3118646787
ENSP00000376197Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2418646787
ENSP00000376197Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineUp16335961
ENSP00000376197Hepatocellular CarcinomaTreatment (none vs resveratrol-treatment)cell lineUp19996131

Hyperphosphorylation site
TFR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRFE_HUMANTFR1_HUMANligand -> receptorHPMR
KPCA_HUMANTFR1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANTFR1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04145Phagosome
hsa04640Hematopoietic cell lineage
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004998transferrin receptor activityNASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0030316osteoclast differentiationIEAbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0009897external side of plasma membraneIEAcellular_component
GO:0005576extracellular regionIDAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneNAScellular_component
GO:0033572transferrin transportTASbiological_process
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0070062extracellular vesicular exosomeIEAcellular_component
GO:0005905coated pitIDAcellular_component
GO:0005886plasma membraneTAScellular_component


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