| UniProt/SwissProt ID: | TFDP2_HUMAN |
| Description: | transcription factor Dp-2 (E2F dimerization partner 2) [Source:HGNC Symbol;Acc:11751] |
| Location: | chr3 q23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S24 | IDQNLsPTKGN | CDK2 | RegPhos |
| S24 | IDQNLsPTKGN | PhosphoSitePlus | |
| S42 | VSNTNsPTKIL | CDK2 | RegPhos |
| S42 | VSNTNsPTKIL | PhosphoSitePlus | |
| Dephosphorylation site |
| TFDP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000420599 | D378N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000439782 | Q301H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000439782 | D378N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000309622 | L160M | COSMIC | Renal Cancer | 20054297 | ENSP00000418590 | L160M | COSMIC | Renal Cancer | 20054297 | ENSP00000439782 | L160M | COSMIC | Renal Cancer | 20054297 | ENSP00000309622 | D378N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000418590 | D378N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000420599 | L160M | COSMIC | Renal Cancer | 20054297 | ENSP00000420599 | Q301H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000309622 | Q301H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000418590 | Q301H | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| TFDP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TFDP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | TFDP2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA poly | TAS | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0000080 | G1 phase of mitotic cell cycle | TAS | biological_process |
| GO:0003712 | transcription cofactor activity | TAS | molecular_function |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |