Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:T2EA_HUMAN
Description:general transcription factor IIE, polypeptide 1, alpha 56kDa [Source:HGNC Symbol;Acc:4650]
Location:chr3 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T285WLREStVQGAYPhosphoSitePlus
Y92TRHNYyFINYRTFIIE_alphaPhosphoSitePlus
S352TAANGsDSESEPhosphoSitePlus
S339SAMAGsVGAAAPhosphoSitePlus
S361SETSEsDDDSPPhosphoSitePlus
S334EKKTSsAMAGSPhosphoSitePlus
S268DLHRAsLEGKSPhosphoSitePlus; HPRD; phosphoELM
T80RMRVEtAADGKTFIIE_alphaPhosphoSitePlus
Y188QIEPIyALLRETFIIE_alphaPhosphoSitePlus
Y250SYEDLyTQNVVPhosphoSitePlus
Y201DVNLAyEILEPPhosphoSitePlus
T8DPDVLtEVPAAPhosphoSitePlus
Y246TKGPSyEDLYTPhosphoSitePlus
T332IHEKKtSSAMAPhosphoSitePlus
T347AAAPVtAANGSPhosphoSitePlus
S333HEKKTsSAMAGPhosphoSitePlus
T98FINYRtLVNVVHPRD
S365ESDDDsPPRPAPhosphoSitePlus
Y91TTRHNyYFINYTFIIE_alphaPhosphoSitePlus

Dephosphorylation site
T2EA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000283875F136LBIOMARTBreast Cancer21930507, 21930502
ENSP00000283875R174CTCGAOvarian Cancer21720365, 18772890
ENSP00000283875Q143PBIOMARTBreast Cancer21930507, 21930502
ENSP00000283875R174CCOSMICOvarian Cancer21720365

Differential expressed protein
T2EA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
T2EA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANT2EA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
T2EA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0016032viral reproductionTASbiological_process


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