| UniProt/SwissProt ID: | SYFM_HUMAN |
| Description: | phenylalanyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:21062] |
| Location: | chr6 p25.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S57 | ELLGKsYPQDD | PhosphoSitePlus | |
| T387 | YDLVRtIGGDL | FDX-ACB | PhosphoSitePlus |
| T246 | FDLKQtLTRLM | tRNA-synt_2d | PhosphoSitePlus |
| Dephosphorylation site |
| SYFM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000274680 | A440S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000316335 | A440S | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SYFM_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SYFM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT3_HUMAN | SYFM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SYFM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008033 | tRNA processing | IDA | biological_process |
| GO:0006418 | tRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0000049 | tRNA binding | IDA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0004826 | phenylalanine-tRNA ligase activity | IDA | molecular_function |
| GO:0043039 | tRNA aminoacylation | IEA | biological_process |
| GO:0006432 | phenylalanyl-tRNA aminoacylation | IDA | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | molecular_function |