| UniProt/SwissProt ID: | SMRCD_HUMAN |
| Description: | SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 [Source:HGNC Symbol;Acc:18398] |
| Location: | chr4 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S302 | DMQYAsQSEVP | phosphoELM | |
| S132 | SEDEEsQGLPT | PhosphoSitePlus; HPRD; phosphoELM | |
| S67 | KTEDSsVPETP | PhosphoSitePlus; HPRD; phosphoELM | |
| S146 | RNDDIsELEDL | PhosphoSitePlus; HPRD; phosphoELM | |
| S314 | GKEVSsRSQNY | PhosphoSitePlus | |
| S57 | ANTPDsDITEK | PhosphoSitePlus; HPRD; phosphoELM | |
| Y82 | KASISyFKNQR | PhosphoSitePlus | |
| S316 | EVSSRsQNYPK | Pox_D5 | PhosphoSitePlus |
| S239 | DHGEEsNESAE | PhosphoSitePlus; HPRD; phosphoELM | |
| S33 | SQPGPsSPISL | HPRD | |
| S152 | ELEDLsELEDL | PhosphoSitePlus; HPRD; phosphoELM | |
| S302 | DMQYVsQSEVP | PhosphoSitePlus; HPRD | |
| S124 | TVIIVsEPSED | PhosphoSitePlus; HPRD; phosphoELM | |
| T119 | TFNKDtVIIVS | HPRD | |
| S801 | KLKEMsQLMLK | PhosphoSitePlus | |
| S34 | QPGPSsPISLS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y897 | HHQHRyLRLDG | Helicase_C | PhosphoSitePlus |
| S245 | NESAEsSSNWE | PhosphoSitePlus | |
| S313 | NGKEVsSRSQN | PhosphoSitePlus | |
| T54 | VSRANtPDSDI | PhosphoSitePlus; HPRD; phosphoELM | |
| S66 | EKTEDsSVPET | PhosphoSitePlus | |
| S212 | KRKLSsSSEPY | PhosphoSitePlus; HPRD; phosphoELM | |
| Y217 | SSSEPyEEDEF | PhosphoSitePlus; HPRD; phosphoELM | |
| T137 | SQGLPtMARRN | PhosphoSitePlus; HPRD | |
| S98 | DLSSDsEDVVS | HPRD; phosphoELM | |
| S423 | LRPFNsWEALF | PhosphoSitePlus | |
| Y91 | QRGIQyIDLSS | HPRD | |
| S95 | QYIDLsSDSED | PhosphoSitePlus; HPRD | |
| S214 | KLSSSsEPYEE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y319 | SRSQNyPKNAT | Pox_D5 | PhosphoSitePlus |
| S127 | IVSEPsEDEES | PhosphoSitePlus; HPRD; phosphoELM | |
| S79 | NERKAsISYFK | PhosphoSitePlus; HPRD; phosphoELM | |
| S211 | RKRKLsSSSEP | PhosphoSitePlus; HPRD; phosphoELM | |
| S37 | PSSPIsLSAEE | PhosphoSitePlus; HPRD; phosphoELM | |
| T880 | LFSQFtMMLDI | PhosphoSitePlus | |
| S103 | SEDVVsPNCSN | HPRD | |
| S213 | RKLSSsSEPYE | PhosphoSitePlus; HPRD; phosphoELM | |
| T114 | TVQEKtFNKDT | PhosphoSitePlus | |
| S50 | AEGEVsRANTP | HPRD | |
| S853 | DLILDsGKFRV | PhosphoSitePlus | |
| S39 | SPISLsAEEEN | PhosphoSitePlus; HPRD; phosphoELM | |
| S96 | YIDLSsDSEDV | PhosphoSitePlus; HPRD; phosphoELM | |
| S242 | EESNEsAESSS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y837 | VLCKQyRHINN | HPRD | |
| Dephosphorylation site |
| SMRCD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000346217 | E22K | COSMIC | Breast Cancer | ENSP00000351947 | S173N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415576 | S173N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000346217 | S173N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000346217 | V888D | COSMIC | Melanoma | 20016485 | ENSP00000423286 | V458D | BIOMART | Melanoma | 21930507, 21930502 |
| Differential expressed protein |
| SMRCD_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SMRCD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK3_HUMAN | SMRCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SMRCD_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016363 | nuclear matrix | NAS | cellular_component |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0006338 | chromatin remodeling | NAS | biological_process |
| GO:0043044 | ATP-dependent chromatin remodeling | IMP | biological_process |
| GO:0043596 | nuclear replication fork | IDA | cellular_component |
| GO:0009117 | nucleotide metabolic process | NAS | biological_process |
| GO:0016568 | chromatin modification | NAS | biological_process |
| GO:0000018 | regulation of DNA recombination | IEP | biological_process |
| GO:0000792 | heterochromatin | ISS | cellular_component |
| GO:0035861 | site of double-strand break | IDA | cellular_component |
| GO:0000792 | heterochromatin | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0051304 | chromosome separation | IMP | biological_process |
| GO:0051260 | protein homooligomerization | NAS | biological_process |
| GO:0003676 | nucleic acid binding | NAS | molecular_function |
| GO:0000729 | DNA double-strand break processing | IMP | biological_process |
| GO:0070932 | histone H3 deacetylation | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070933 | histone H4 deacetylation | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004386 | helicase activity | IEA | molecular_function |