Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SLX4_HUMAN
Description:SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:23845]
Location:chr16 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1065RSRGGtSQVGSPhosphoSitePlus
S71GIKEVsGERKTPhosphoSitePlus
S499EVELSsTPPLPPhosphoSitePlus
S1333VSPGTsDGRRQPhosphoSitePlus
S467KKPPVsPPLLLPhosphoSitePlus
S1322PPQTPsSCLTPPhosphoSitePlus
S1271SRDCSsQTQISPhosphoSitePlus
S1044PPQGGsPRGSHPhosphoSitePlus; HPRD
S1323PQTPSsCLTPVPhosphoSitePlus
S884WLEGGsPVSGQPhosphoSitePlus; HPRD
S1716DSSLSsQSSSSPhosphoSitePlus
S1631CQTLAsQTYKPPhosphoSitePlus
S383PEGSSsPPMFSPhosphoSitePlus
T1326PSSCLtPVSPGPhosphoSitePlus
S1674RKHHEsITPPSHPRD
S1309VAQKFsVIRPQPhosphoSitePlus
T1273DCSSQtQISSLPhosphoSitePlus
S287SAHDDsLEEKGPhosphoSitePlus; HPRD
S228RLRHAsEECSLPhosphoSitePlus
S1157ILLLDsDEELEPhosphoSitePlus
S1070TSQVGsPTLLSPhosphoSitePlus; HPRD
S956EALGHsSCSSPPhosphoSitePlus
T1475PGLLDtTPIRGHPRD
T500VELSStPPLPAPhosphoSitePlus
S1185KALEIsPRSCEPhosphoSitePlus; HPRD
T1332PVSPGtSDGRRPhosphoSitePlus
T478VQDSEtTGRQIPhosphoSitePlus
S1138HSSSRsQKSSSPhosphoSitePlus
S1452GPLSTsSPSRRPhosphoSitePlus; HPRD
S1453PLSTSsPSRRMPhosphoSitePlus; HPRD
S601GSRGPsPSASQPhosphoSitePlus
S1679SITPPsRSPTKHPRD
T1320TPPPQtPSSCLPhosphoSitePlus
T590PALHGtPTAGCPhosphoSitePlus
S1264ATPLAsRSRDCPhosphoSitePlus
S1075SPTLLsPAVPSPhosphoSitePlus; HPRD
T1315VIRPQtPPPQTPhosphoSitePlus
S1469SRDCRsPGLLDPhosphoSitePlus; HPRD
S1329CLTPVsPGTSDPhosphoSitePlus
S173PSPNLsREKTRPhosphoSitePlus

Dephosphorylation site
SLX4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000294008W1428CCOSMICOvarian Cancer21720365
ENSP00000294008A1283VCOSMICMelanoma21499247
ENSP00000294008R1791CCOSMICSkin Cancer21984974
ENSP00000294008E456DBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
SLX4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SLX4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANSLX4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SLX4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0006289nucleotide-excision repairIMPbiological_process
GO:0033557Slx1-Slx4 complexIDAcellular_component
GO:0008821crossover junction endodeoxyribonuclease activityIDAmolecular_function
GO:00171085'-flap endonuclease activityIDAmolecular_function
GO:0070522ERCC4-ERCC1 complexIDAcellular_component
GO:0000724double-strand break repair via homologous recombinIMPbiological_process
GO:0043085positive regulation of catalytic activityIDAbiological_process
GO:00482573'-flap endonuclease activityIDAmolecular_function
GO:0006281DNA repairIMPbiological_process
GO:0008047enzyme activator activityIDAmolecular_function
GO:0048476Holliday junction resolvase complexIDAcellular_component
GO:0000784nuclear chromosome, telomeric regionIDAcellular_component
GO:0000790nuclear chromatinIDAcellular_component
GO:0010792DNA double-strand break processing involved in repIMPbiological_process


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