| UniProt/SwissProt ID: | SGK2_HUMAN |
| Description: | serum/glucocorticoid regulated kinase 2 [Source:HGNC Symbol;Acc:13900] |
| Location: | chr20 q13.12 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T253 | EDTTStFCGTP | Pkinase_AGC | PhosphoSitePlus |
| S416 | AFLGFsYAPED | PDK1 | RegPhos |
| S356 | AFLGFsYAPED | PDPK1 | HPRD |
| T253 | EDTTStFCGTP | PDK1 | RegPhos |
| T253 | EDTTStFCGTP | PDPK1 | HPRD |
| S416 | AFLGFsYAPED | RegPhos | |
| T193 | EDTTStFCGTP | PDPK1 | HPRD |
| Y285 | LGAVLyEMLHG | Pkinase_AGC | PhosphoSitePlus |
| S416 | AFLGFsYAPED | PDPK1 | HPRD |
| T253 | EDTTStFCGTP | PDK-1 | phosphoELM |
| T251 | EPEDTtSTFCG | Pkinase_AGC | PhosphoSitePlus |
| Dephosphorylation site |
| SGK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340608 | E304K | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000340608 | R152G | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000340608 | E259K | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| SGK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SGK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | SGK2_HUMAN | kinase -> substrate | RegPhos |
| SGK2_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | SGK2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| SGK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007243 | intracellular protein kinase cascade | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0032411 | positive regulation of transporter activity | TAS | biological_process |
| GO:0006979 | response to oxidative stress | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0015459 | potassium channel regulator activity | IDA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0042127 | regulation of cell proliferation | TAS | biological_process |
| GO:0017080 | sodium channel regulator activity | NAS | molecular_function |
| GO:0001558 | regulation of cell growth | TAS | biological_process |