Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SGK2_HUMAN
Description:serum/glucocorticoid regulated kinase 2 [Source:HGNC Symbol;Acc:13900]
Location:chr20 q13.12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T253EDTTStFCGTPPkinase_AGCPhosphoSitePlus
S416AFLGFsYAPEDPDK1RegPhos
S356AFLGFsYAPEDPDPK1HPRD
T253EDTTStFCGTPPDK1RegPhos
T253EDTTStFCGTPPDPK1HPRD
S416AFLGFsYAPEDRegPhos
T193EDTTStFCGTPPDPK1HPRD
Y285LGAVLyEMLHGPkinase_AGCPhosphoSitePlus
S416AFLGFsYAPEDPDPK1HPRD
T253EDTTStFCGTPPDK-1phosphoELM
T251EPEDTtSTFCGPkinase_AGCPhosphoSitePlus

Dephosphorylation site
SGK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340608E304KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000340608R152GBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000340608E259KGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
SGK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SGK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSGK2_HUMANkinase -> substrateRegPhos
SGK2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSGK2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
SGK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationNASbiological_process
GO:0032411positive regulation of transporter activityTASbiological_process
GO:0006979response to oxidative stressTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0015459potassium channel regulator activityIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005575cellular_componentNDcellular_component
GO:0042127regulation of cell proliferationTASbiological_process
GO:0017080sodium channel regulator activityNASmolecular_function
GO:0001558regulation of cell growthTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23