| UniProt/SwissProt ID: | ROBO4_HUMAN |
| Description: | roundabout, axon guidance receptor, homolog 4 (Drosophila) [Source:HGNC Symbol;Acc:17985] |
| Location: | chr11 q24.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S3 | ___MGsGGDSL | PhosphoSitePlus | |
| S656 | LQHANsSPLLR | PhosphoSitePlus | |
| S542 | DLSSSsSLSSR | HPRD | |
| S539 | GSRDLsSSSSL | HPRD | |
| S131 | RGARLsVAVLR | I-set | PhosphoSitePlus |
| Dephosphorylation site |
| ROBO4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000304945 | G328D | COSMIC | Skin Cancer | 21984974 | ENSP00000304945 | A495D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304945 | L703F | COSMIC | Skin Cancer | 21984974 | ENSP00000304945 | W162* | COSMIC | Skin Cancer | 21984974 | ENSP00000304945 | G662A | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ROBO4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ROBO4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SLIT2_HUMAN | ROBO4_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| ROBO4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030334 | regulation of cell migration | NAS | biological_process |
| GO:0001525 | angiogenesis | IGI | biological_process |
| GO:0016021 | integral to membrane | TAS | cellular_component |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0030336 | negative regulation of cell migration | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |