| UniProt/SwissProt ID: | RIC8A_HUMAN |
| Description: | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) [Source:HGNC Symbol;Acc:29550] |
| Location: | chr11 p15.5 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S534 | SSDPDsD | HPRD | |
| S523 | EQQLSsDPDSD | phosphoELM | |
| Y434 | RPEGQySEDED | phosphoELM | |
| S435 | PEGQYsEDEDT | phosphoELM | |
| S436 | PEGQYsEDEDT | Ric8 | PhosphoSitePlus |
| S74 | SVRILsRDRNC | Ric8 | PhosphoSitePlus |
| Y446 | TDTDEyKEAKA | Ric8 | PhosphoSitePlus |
| S30 | YNQEHsQSFTF | PhosphoSitePlus; HPRD; phosphoELM | |
| T449 | DEDTDtDEYKE | HPRD | |
| Y441 | RPEGQySEDED | HPRD | |
| Y445 | TDTDEyKEAKA | phosphoELM | |
| S508 | QPMGMsPRGHL | HPRD | |
| T442 | DEDTDtDEYKE | phosphoELM | |
| S529 | MEQQLsSDPDS | HPRD | |
| S452 | KEAKAsINPVT | Ric8 | PhosphoSitePlus |
| S442 | PEGQYsEDEDT | HPRD | |
| S530 | EQQLSsDPDSD | HPRD | |
| S527 | SSDPDsD | phosphoELM | |
| T485 | AMKLVtMFDKL | Ric8 | PhosphoSitePlus |
| T441 | SEDEDtDTDEY | Ric8 | PhosphoSitePlus |
| S523 | MEQQLsSDPDS | PhosphoSitePlus | |
| S522 | MEQQLsSDPDS | phosphoELM | |
| S502 | QPMGMsPRGHL | Ric8 | PhosphoSitePlus |
| S524 | EQQLSsDPDSD | PhosphoSitePlus | |
| S501 | QPMGMsPRGHL | phosphoELM | |
| S528 | SSDPDsDPD__ | PhosphoSitePlus | |
| T440 | SEDEDtDTDEY | phosphoELM | |
| Y435 | RPEGQySEDED | Ric8 | PhosphoSitePlus |
| T443 | DEDTDtDEYKE | Ric8 | PhosphoSitePlus |
| Y452 | TDTDEyKEAKA | HPRD | |
| T447 | SEDEDtDTDEY | HPRD | |
| Dephosphorylation site |
| RIC8A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000325941 | R267C | COSMIC | Skin Cancer | 21984974 | ENSP00000432008 | *532R | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| RIC8A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RIC8A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAQ_HUMAN | RIC8A_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| RIC8A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | IEA | biological_process |
| GO:0070586 | cell-cell adhesion involved in gastrulation | IEA | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0042074 | cell migration involved in gastrulation | IEA | biological_process |
| GO:0005886 | plasma membrane | ISS | cellular_component |
| GO:0008542 | visual learning | IEA | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0071711 | basement membrane organization | IEA | biological_process |
| GO:0009416 | response to light stimulus | IEA | biological_process |
| GO:0001944 | vasculature development | IEA | biological_process |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007369 | gastrulation | IEA | biological_process |