| UniProt/SwissProt ID: | RFA4_HUMAN |
| Description: | replication protein A4, 30kDa [Source:HGNC Symbol;Acc:30305] |
| Location: | chrX q21.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| RFA4_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| RFA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362131 | V59L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000362131 | V59L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RFA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RFA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | RFA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RFA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RFA4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0006289 | nucleotide-excision repair | IDA | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0003697 | single-stranded DNA binding | TAS | molecular_function |
| GO:0005662 | DNA replication factor A complex | IDA | cellular_component |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000077 | DNA damage checkpoint | IDA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |