| UniProt/SwissProt ID: | RAP1B_HUMAN |
| Description: | RAP1B, member of RAS oncogene family [Source:HGNC Symbol;Acc:9857] |
| Location: | chr12 q15 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S179 | KARKKsSCQ | PKG1/cGK-I | phosphoELM |
| S11 | LVVLGsGGVGK | Ras | PhosphoSitePlus |
| S179 | KARKKsSCQLL | PKA_group | RegPhos |
| S179 | KARKKsSCQLL | PKACa | RegPhos |
| S179 | KARKKsSCQ | PRKACA | HPRD |
| S39 | PTIEDsYRKQV | Ras | PhosphoSitePlus |
| Y159 | VNEIFyDLVRQ | Ras | PhosphoSitePlus |
| S179 | KARKKsSCQ | PKA_group | phosphoELM |
| S180 | ARKKSsCQLL_ | PhosphoSitePlus | |
| S179 | KARKKsSCQLL | PhosphoSitePlus | |
| S179 | KARKKsSCQLL | PKG1 | RegPhos |
| Dephosphorylation site |
| RAP1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000250559 | Q25E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377085 | Q25E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377085 | L9F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000250559 | L9F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| RAP1B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAP1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | RAP1B_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| hsa04010 | MAPK signaling pathway |
| hsa05211 | Renal cell carcinoma |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04972 | Pancreatic secretion |
| hsa04062 | Chemokine signaling pathway |
| hsa04720 | Long-term potentiation |
| hsa04510 | Focal adhesion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032045 | guanyl-nucleotide exchange factor complex | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:2000114 | regulation of establishment of cell polarity | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005811 | lipid particle | IDA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005911 | cell-cell junction | IDA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |