Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRP8_HUMAN
Description:PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:17340]
Location:chr17 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y2062STTSNyETQTFPhosphoSitePlus
S1027MNHTNsYGIIRHPRD
S2093NHIYVsSDDIKPhosphoSitePlus
Y239MMSTLyRLANQPhosphoSitePlus; HPRD
S236TLPMMsTLYRLHPRD
T645FMRGItPLLERPROCNPhosphoSitePlus
Y2102IKETGyTYILPMov34PhosphoSitePlus
Y1028NHTNSyGIIRGHPRD
Y394KDTPLyTDNTAPROCNPhosphoSitePlus
Y1991LILADyGKKNNPhosphoSitePlus; HPRD
Y1113DLIQRyLTEHPPhosphoSitePlus
Y742NMILRyVKAKAPROCNPhosphoSitePlus
Y2091RTNHIyVSSDDPhosphoSitePlus
S679KQRVEsHFDLEPROCNPhosphoSitePlus
Y1470WNLNNyRTDMIPhosphoSitePlus; HPRD
T2064TSNYEtQTFSSPhosphoSitePlus; HPRD; phosphoELM
Y1432RHTLAyDKGWRPhosphoSitePlus
T1404QNRRLtLEDLEPhosphoSitePlus
S859SRLNQsQREELPhosphoSitePlus; HPRD
S1355ITHFRsGMSHEHPRD
T2087NLHLRtNHIYVPhosphoSitePlus; HPRD
Y1091RLFCRyIDRIHPhosphoSitePlus
T247ANQLLtDLVDDHPRD
Y254LVDDNyFYLFDHPRD
Y1128ENIVGyNNKKCPhosphoSitePlus
T2042SQLTAtQTRTVPhosphoSitePlus; HPRD; phosphoELM
T733VPGLPtPIENMPROCNPhosphoSitePlus
S2037QTKEQsQLTATPhosphoSitePlus
T1608ALEIEtVQKETPhosphoSitePlus
S2079RVRAIsAANLHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1204KCRTSyEEFTHPhosphoSitePlus
S1539FTLWWsPTINRPhosphoSitePlus; HPRD; phosphoELM
T237LPMMStLYRLAHPRD
Y1369LIPNLyRYIQPHPRD
Y501VCRQGyNMLNLPROCNPhosphoSitePlus
S2205MADNPsWDGEKMov34PhosphoSitePlus

Dephosphorylation site
PRP8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000304350S26LCOSMICHead and Neck Cancer21798893
ENSP00000304350S26LCOSMICHead and Neck Cancer21798893
ENSP00000304350M1591RCOSMICHead and Neck Cancer21798893
ENSP00000304350N1069DCOSMICLung Cancer20016488
ENSP00000304350R998PCOSMICOvarian Cancer21720365
ENSP00000304350D1592NCOSMICHead and Neck Cancer21798893
ENSP00000304350R998PCOSMICOvarian Cancer21720365
ENSP00000304350E199KCOSMICHead and Neck Cancer21984974
ENSP00000304350N1069DCOSMICLung Cancer20016488
ENSP00000304350M1591RCOSMICHead and Neck Cancer21798893
ENSP00000304350D1592NCOSMICHead and Neck Cancer21798893
ENSP00000304350R820CCOSMICLung Cancer20668451
ENSP00000304350R820CCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000304350Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PRP8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANPRP8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRP8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0000375RNA splicing, via transesterification reactionsTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005682U5 snRNPTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0006397mRNA processingTASbiological_process
GO:0005681spliceosomal complexIEAcellular_component


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