| UniProt/SwissProt ID: | PRP8_HUMAN |
| Description: | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:17340] |
| Location: | chr17 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y2062 | STTSNyETQTF | PhosphoSitePlus | |
| S1027 | MNHTNsYGIIR | HPRD | |
| S2093 | NHIYVsSDDIK | PhosphoSitePlus | |
| Y239 | MMSTLyRLANQ | PhosphoSitePlus; HPRD | |
| S236 | TLPMMsTLYRL | HPRD | |
| T645 | FMRGItPLLER | PROCN | PhosphoSitePlus |
| Y2102 | IKETGyTYILP | Mov34 | PhosphoSitePlus |
| Y1028 | NHTNSyGIIRG | HPRD | |
| Y394 | KDTPLyTDNTA | PROCN | PhosphoSitePlus |
| Y1991 | LILADyGKKNN | PhosphoSitePlus; HPRD | |
| Y1113 | DLIQRyLTEHP | PhosphoSitePlus | |
| Y742 | NMILRyVKAKA | PROCN | PhosphoSitePlus |
| Y2091 | RTNHIyVSSDD | PhosphoSitePlus | |
| S679 | KQRVEsHFDLE | PROCN | PhosphoSitePlus |
| Y1470 | WNLNNyRTDMI | PhosphoSitePlus; HPRD | |
| T2064 | TSNYEtQTFSS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1432 | RHTLAyDKGWR | PhosphoSitePlus | |
| T1404 | QNRRLtLEDLE | PhosphoSitePlus | |
| S859 | SRLNQsQREEL | PhosphoSitePlus; HPRD | |
| S1355 | ITHFRsGMSHE | HPRD | |
| T2087 | NLHLRtNHIYV | PhosphoSitePlus; HPRD | |
| Y1091 | RLFCRyIDRIH | PhosphoSitePlus | |
| T247 | ANQLLtDLVDD | HPRD | |
| Y254 | LVDDNyFYLFD | HPRD | |
| Y1128 | ENIVGyNNKKC | PhosphoSitePlus | |
| T2042 | SQLTAtQTRTV | PhosphoSitePlus; HPRD; phosphoELM | |
| T733 | VPGLPtPIENM | PROCN | PhosphoSitePlus |
| S2037 | QTKEQsQLTAT | PhosphoSitePlus | |
| T1608 | ALEIEtVQKET | PhosphoSitePlus | |
| S2079 | RVRAIsAANLH | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y1204 | KCRTSyEEFTH | PhosphoSitePlus | |
| S1539 | FTLWWsPTINR | PhosphoSitePlus; HPRD; phosphoELM | |
| T237 | LPMMStLYRLA | HPRD | |
| Y1369 | LIPNLyRYIQP | HPRD | |
| Y501 | VCRQGyNMLNL | PROCN | PhosphoSitePlus |
| S2205 | MADNPsWDGEK | Mov34 | PhosphoSitePlus |
| Dephosphorylation site |
| PRP8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000304350 | S26L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | S26L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | M1591R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | N1069D | COSMIC | Lung Cancer | 20016488 | ENSP00000304350 | R998P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304350 | D1592N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | R998P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304350 | E199K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000304350 | N1069D | COSMIC | Lung Cancer | 20016488 | ENSP00000304350 | M1591R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | D1592N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000304350 | R820C | COSMIC | Lung Cancer | 20668451 | ENSP00000304350 | R820C | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000304350 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| PRP8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | PRP8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PRP8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005682 | U5 snRNP | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0071013 | catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0005681 | spliceosomal complex | IEA | cellular_component |