Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRDX5_HUMAN
Description:peroxiredoxin 5 [Source:HGNC Symbol;Acc:9355]
Location:chr11 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T97VPGAFtPGCSKAhpC-TSAPhosphoSitePlus; SysPTM
S34AARRYsEGEWAPhosphoSitePlus
S182RLKRFsMVVQDAhpC-TSAPhosphoSitePlus

Dephosphorylation site
PRDX5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265462F157LSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265462Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3518646787
ENSP00000265462Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3418646787
ENSP00000265462Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000265462Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.316319398
ENSP00000265462Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000265462Non-small cell lung carcinomaMetastasiscell lineDown0.1517418446
ENSP00000265462Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineUp3.816900703
ENSP00000265462Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000265462Gastric CancerNormal vs. CancertissueDown0.3819424620
ENSP00000265462Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.6420625496

Hyperphosphorylation site
PRDX5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPRDX5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRDX5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016480negative regulation of transcription from RNA polyIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0004601peroxidase activityIDAmolecular_function
GO:0001016RNA polymerase III regulatory region DNA bindingIDAmolecular_function
GO:2001057reactive nitrogen species metabolic processIDAbiological_process
GO:0072541peroxynitrite reductase activityIDAmolecular_function
GO:0070995NADPH oxidationIDAbiological_process
GO:0060785regulation of apoptosis involved in tissue homeostIDAbiological_process
GO:0044445cytosolic partIDAcellular_component
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0005782peroxisomal matrixIDAcellular_component
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0051354negative regulation of oxidoreductase activityIDAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0042744hydrogen peroxide catabolic processIDAbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIMPmolecular_function
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0034614cellular response to reactive oxygen speciesIMPbiological_process
GO:0006979response to oxidative stressIDAbiological_process
GO:2001141regulation of RNA biosynthetic processIDAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0051920peroxiredoxin activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0005777peroxisomeIDAcellular_component
GO:0005777peroxisomeIEAcellular_component
GO:0016209antioxidant activityIDAmolecular_function
GO:0046983protein dimerization activityIDAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process


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