Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLD2_HUMAN
Description:phospholipase D2 [Source:HGNC Symbol;Acc:9068]
Location:chr17 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S416INSGYsKRALMPhosphoSitePlus
Y573TTKAKyKTPTYPhosphoSitePlus
T488ASQPPtPRPDSPhosphoSitePlus
S243LVVKDsFLLYMPKC_alphaphosphoELM
S609VQVLRsVDRWSHPRD
T252YMCLEtGAISFPKC_alphaphosphoELM
Y511WLGKDySNLITPhosphoSitePlus
T99GDFSWtTKKKYphosphoELM; RegPhos
Y179LTMSFyRNYHAEGFRHPRD; RegPhos
T99GDFSWtTKKKYPXPhosphoSitePlus
Y179LTMSFyRNYHAPXPhosphoSitePlus
Y578YKTPTyPYLLPPhosphoSitePlus
S243LVVKDsFLLYMPHPhosphoSitePlus
Y169KYLENyLNRLLPXPhosphoSitePlus
Y415GINSGySKRALPhosphoSitePlus
T72AQVVGtERYTSPXPhosphoSitePlus
S146NREMPsLPRAGphosphoELM; RegPhos
T72AQVVGtERYTSphosphoELM; RegPhos
S146NREMPsLPRAGPXPhosphoSitePlus
S134FAVAYsPARDAphosphoELM; RegPhos
T100DFSWTtKKKYRPXPhosphoSitePlus
S243LVVKDsFLLYMPKCa(PKC alphaRegPhos
S213MIRKRsGGHRVPHPhosphoSitePlus
T566QRWNFtKTTKAPhosphoSitePlus
T252YMCLEtGAISFPHPhosphoSitePlus
S134FAVAYsPARDAPXPhosphoSitePlus
T175LNRLLtMSFYRPXPhosphoSitePlus
Y580TPTYPyLLPKSPhosphoSitePlus
T100DFSWTtKKKYRphosphoELM; RegPhos
S161TRHAAsKQKYLPXPhosphoSitePlus
Y296LKCSSyRQARWPHPhosphoSitePlus
T252YMCLEtGAISFPKCa(PKC alphaRegPhos

Dephosphorylation site
PLD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263088E851KCOSMICHead and Neck Cancer21798897
ENSP00000263088Q807ESjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263088Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PLD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPLD2_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANPLD2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANPLD2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04144Endocytosis
hsa00565Ether lipid metabolism
hsa04666Fc gamma R-mediated phagocytosis
hsa04912GnRH signaling pathway
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0006654phosphatidic acid biosynthetic processTASbiological_process
GO:0070290NAPE-specific phospholipase D activityIEAmolecular_function
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0004630phospholipase D activityIEAmolecular_function
GO:0046474glycerophospholipid biosynthetic processTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0006655phosphatidylglycerol biosynthetic processTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0031526brush border membraneIEAcellular_component
GO:0016042lipid catabolic processIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0007010cytoskeleton organizationTASbiological_process


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