Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLD1_HUMAN
Description:phospholipase D1, phosphatidylcholine-specific [Source:HGNC Symbol;Acc:9067]
Location:chr3 q26.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S561KFSKFsLYKQLPKCaRegPhos
Y433GINSEyTKRTLPhosphoSitePlus
S561KFSKFsLYKQLPRKCAHPRD
S2KNEPPRKCAHPRD
T495NEHRLtDVGSVPhosphoSitePlus
S611LFHPSsESEQGPhosphoSitePlus
Y42GEEVDyDVSPSPhosphoSitePlus
Y711IMKSKyRSLSYPhosphoSitePlus
S2MSLKNePPKCaRegPhos
Y590SYFNHyRSHHNPhosphoSitePlus
S629TGSIRsLQTGVHPRD; phosphoELM; RegPhos; SysPTM
Y586DSTSSyFNHYRPhosphoSitePlus
T147PTRRHtFRRQNPRKCAHPRD
S610KLFHPsSESEQPhosphoSitePlus
S431ALGINsEYTKRPhosphoSitePlus
S45VDYDVsPSDPKPhosphoSitePlus; HPRD; phosphoELM
S505VKRVTsGPSLGPhosphoSitePlus
S508VTSGPsLGSLPPhosphoSitePlus
T147PTRRHtFRRQNPKCaRegPhos

Dephosphorylation site
PLD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342793D980YCOSMICSkin Cancer21984974
ENSP00000342793H608LCOSMICOvarian Cancer21720365
ENSP00000342793E204KCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000342793Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.2915169874

Hyperphosphorylation site
PLD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPLD1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPLD1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa00564Glycerophospholipid metabolism
hsa04724Glutamatergic synapse
hsa01100Metabolic pathways
hsa00565Ether lipid metabolism
hsa04666Fc gamma R-mediated phagocytosis
hsa05212Pancreatic cancer
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000139Golgi membraneIEAcellular_component
GO:0031902late endosome membraneIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0046474glycerophospholipid biosynthetic processTASbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0070290NAPE-specific phospholipase D activityIEAmolecular_function
GO:0006654phosphatidic acid biosynthetic processTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0006655phosphatidylglycerol biosynthetic processTASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005768endosomeIDAcellular_component
GO:0007154cell communicationIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006935chemotaxisTASbiological_process
GO:0004630phospholipase D activityIEAmolecular_function
GO:0016020membraneTAScellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23